Mechanical Ventilation, Thoracic Diseases
Conditions
Brief summary
. The aim of this study, thus, is to evaluate shunt fraction and markers of alveolar distress during one lung ventilation (OLV) at different levels of positive end expiratory pressure (PEEP). Moreover, investigators will focus on predicting factors of high shunt levels during OLV.
Interventions
None listed
Sponsors
Università degli Studi di Ferrara
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients scheduled for thoracoscopic lobectomy or thoracoscopic wedge resection in lateral decubitus. * patients American Society of Anesthesiologists Physical Status Classification score of 1-3
Exclusion criteria
* Patients with hemodynamic instability, * Patients with severe chronic respiratory failure * Patients with preoperative anemia (hemoglobin \<10 g 100 ml-1) * Patients requiring unplanned conversion to thoracotomy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pulmonary shunt evaluated with ALPE system | every 30 minutes after the start of surgery up to 3 evaluations, up to 90 minutes |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| predictors of high intraoperative shunt | The outcome is assessed 15 minutes after one lung ventilation | All patients admitted to the study received a preoperative physiologic assessment with a cardiovascular evaluation and spirometry. After 15 minutes of one lung ventilation, the pulmonary shunt is evaluated. Therefore, all clinical variable evaluated during preoperative assessment will be compared with the pulmonary shunt |
Countries
Italy
Outcome results
None listed