CARdioprotection in Myocardial Infarction

Myocardial Infarct

clinical confounders, myocardial infarction size, determinants of myocardial infarct injury

CARIM is a prospective cohort of 2,000 patients with a first myocardial infarction and undergoing reperfusion therapy. Therefore, male and female patients older than 18 years and younger than 90 years with onset of chest pain of less than 12 hours who need a primary percutaneous coronary intervention (PCI) for a ST elevation segment MI (STEMI) will be recruited.

In the setting of research in ischemic cardiomyopathy, the CARIM cohort aims to meet the expectation and strategy of Aviesan (Alliance nationale pour les sciences de la VIE et de la SANté) since it will address the underlying pathophysiology of the determinants of MI injury and its impact on follow-up, in addition with the potential confounding clinical and biological factors. Therefore, CARIM cohort will offer a great opportunity of describing the interactions between myocardial infarction and surrounding environment (clinical, social and professional). This cohort will use complementary state of the art approaches (cardiac imaging including Cardiovascular Magnetic Resonance and echocardiography, biomarkers, proteomic, genetic and pharmacogenetics) with strong interactions between the different partners. Therefore CARIM cohort should help to obtain a modeling of the determinants of the MI size. The investigators expect that CARIM cohort will provide new imaging or biological markers that may bring early information regarding the severity of lethal reperfusion injury. By optimizing the knowledge on infarct injury in addition with a 5-year clinical and echographic follow-up, this cohort will better stratify the prognosis after MI and will therefore give new insights in identifying patients at higher risk of left ventricular remodeling and subsequent heart failure. It will therefore help and emphasize prevention messages and patients' education. The aim is to translate this information directly into patient care by using the science generated by this project to develop new management guidelines and novel clinical tools (confounder-annotated database, imaging and biological biomarkers). This cohort may have additional impact in patient care by adapting the treatment to patient-related confounders (age, diabetes...), genetic polymorphisms and thus personalizing health care to individuals. 3.2 MAIN OBJECTIVE The investigators main objective is to create a prospective cohort of 2,000 patients (CARIM cohort) with a first myocardial infarction and undergoing reperfusion therapy in order to evaluate the impact of patient-related confounders on myocardial infarct size and LRI in order to further design a modeling of myocardial infarct size. For this purpose, CARIM cohort will be associated with the creation of a non-invasive cardiac imaging data-bank (MRI and echocardiography) in addition with a large bio-bank relying on existing biological certified platforms (i.e. BRC network). This cohort will provide a population of first acute MI, optimally characterized in terms of comprehensive clinical and angiography phenotype, specifically characterized by CMR in terms of infarct size and LRI and by echocardiography in terms of myocardial regional function and left ventricular remodeling. 3.3 SECONDARY OBJECTIVES 1. Evaluate the specific impact of myocardial infarct injury on myocardial regional function and left ventricular remodeling (defined by an increase in LV end-diastolic volume \> 20% between week 1 and month 12 post-MI by echocardiography). 2. Evaluate the power of the myocardial infarct injury in predicting cardiovascular events (rehospitalizations, reinfarction, occurrence of HF, transplantation, arrhythmias, death) in a 5-year patient follow-up. 3. Test the value of established or newly identified plasma/serum biomarkers to identify LRI and to predict post-MI LV remodeling and progression towards CHF during a 5 year follow-up. 4. This cohort aims ultimately at defining the profile of the MI patient population to be used for future trials implementing new protective interventions targeting LRI.

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