Effect of Pranayama on Periodontal Health

Effect of Pranayama on Peroxisome Proliferator-activated Receptor Gamma, Nuclear Factor Kappa B and Red Complex Microorganisms in Patients With Chronic Periodontitis

Status

Completed

Phases

Early Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02967861

Enrollment

Registered

2016-11-18

Start date

2016-01-31

Completion date

2016-07-31

Last updated

2016-11-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Periodontitis

Keywords

chronic periodontitis, Nuclear factor-kappa B, Pranayama, Peroxisome proliferator - activated receptor gamma, Red complex microorganisms

Brief summary

The objective of the study was to evaluate the levels of Peroxisome proliferator-activated receptor gamma (PPAR-γ), Nuclear factor-kappa B (NF-kB) and the presence of red complex microorganisms (RCM) such as Treponema denticola (T.d), Porphyromonas gingivalis (P.g) and Tannerella forsythia (T.f) in the subgingival tissues of chronic periodontitis subjects before and after intervention with pranayama as an adjunct to scaling and root planing.

Detailed description

Sixty chronic periodontitis subjects were selected out of which 30 subjects (control group) were treated with scaling and root planing (SRP) and 30 subjects (pranayama group) also underwent SRP and pranayama for 3 months. Clinical parameters were recorded and the presence of PPAR-γ, NF-kB and RCM were assessed at baseline and after 3 months

Interventions

BEHAVIORALPranayama

Pranayama is the breathing exercise through the nostrils. It enhances the systemic immunity which in turn enhances the overall defense mechanism of an individual.

PROCEDUREScaling and root planing

It is a mechanical debridement of dental plaque.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Investigator)

Eligibility

Sex/Gender

ALL

Age

30 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* presence of at least 20 teeth * Probing pocket depth ≥ 5 mm

Exclusion criteria

* aggressive periodontitis * systemic disorders * pregnant & lactating females * smokers & alcoholics * immunocompromised individuals

Design outcomes

Primary

Measure	Time frame	Description
Clinical efficacy of pranayama in chronic periodontitis patients from baseline to 3 months	3 months	Clinical attachment level is measured using Williams periodontal probe in millimeters with the criteria of 1 to 2 mm for slight periodontitis, 3 to 4 mm for moderate periodontits and greater or equal to 5 mm for severe periodontitis.

Secondary

Measure	Time frame	Description
Microbiological efficacy of pranayama in chronic periodontitis patients from baseline to 3 months	3 months	Red complex microorganisms such as P.gingivalis, T.denticola, T.forsythia are identified as '0' for absence and '1' for presence and analysed using polymerase chain reaction from subgingival plaque samples.
Efficacy of pranayama on nuclear factor-kappa B (NF-kB) in chronic periodontitis patients	3 months	The expression of NF-kB is analysed using Real time PCR after isolation of RNA from subgingival plaque samples.
Efficacy of pranayama on perosxisome proliferator-activated receptor (PPAR)-γ in chronic periodontitis patients	3 months	The expression of PPAR- γ is analysed using Real time PCR after isolation of RNA from subgingival plaque samples.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026