Etiology, Epidemiology and Prognostics of AKI

The Study of Etiology, Epidemiology and Prognostic Factors of Acute Kidney Injury

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02967263

Enrollment

713

Registered

2016-11-18

Start date

2015-01-31

Completion date

2024-06-30

Last updated

2023-11-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Kidney Injury

Keywords

Acute Kidney Injury, Proteinosis, Epidemiology, Risk factors

Brief summary

* To investigate the etiology and epidemiology of acute kidney injury (AKI). * To find out risk factors associated with the occurence of AKI. * To find out risk factors related to the prognosis of AKI,focusing on uremic toxins, inflammation, oxidative stress and nutritional status. * To study on the relationship between gene polymorphism and prognosis of acute kidney injury.

Detailed description

1. To investigate the relationship between preexisting protein-energy wasting (PEW) and adverse outcomes in patients with AKI. 2. To evaluate the association of serum nutritional variables and prognosis of AKI. 3. Given the different half-lives of serum nutritional markers, we hypothesized that the utility of serum nutritional variables as prognostic predictors may differ in early death (\<7 days) and late death (\>7 days, \<28 days) patients. 4. To investigate the various kinds of uremic toxins in AKI, furthermore, to evaluate the relationship between uremic toxins, especially protein bound toxins, and short- or long-term mortality in AKI patients. 5. To investigate the mineral bone disorders in AKI,and to evaluate whether these markers would role as prognostic predictors of AKI. 6. Several risk factors of mortality in AKI,such as markers of PEW, inflammation and serum creatinine,have been used; however, no single indicator is considered to be a gold standard.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 89 Years

Healthy volunteers

Yes

Inclusion criteria

* age \>=18 years and \<= 88 years * clinically diagnosed with acute kidney injury, according KDIGO criteria.

Exclusion criteria

* preexisting chronic kidney failure (defined as an eGFR \<60 ml/min per 1.73 m2) * post-renal obstruction or rapid progressive glomerulonephritis as the main cause of AKI * known acute renal dysfunction * hospital stays \<24 hours * malignancy

Design outcomes

Primary

Measure	Time frame
all-cause mortality	90 days

Secondary

Measure	Time frame
renal function survival rate	90 days
days in hospital	90 days

Countries

China

Contacts

Primary ContactFeng Ding, PhD

dingfeng@sjtu.edu.cn86-21-53315165

Outcome results