Aortitis, Churg-Strauss Syndrome, Cutaneous Vasculitis, Eosinophilic Granulomatosis With Polyangiitis, Giant Cell Arteritis, Granulomatosis With Polyangiitis (Wegener's), Henoch-Schonlein Purpura, IgA Vasculitis, Microscopic Polyangiitis, Polyarteritis Nodosa, Takayasu Arteritis
Conditions
Keywords
CSS, EGPA, GCA, GPA, MPA, PAN, TAK, HSP
Brief summary
The purpose of this study is to collect existing tissue specimens from subjects enrolled in Vasculitis Clinical Research Consortium (VCRC) studies. Analysis of these tissue specimens and linked clinical data collected through VCRC studies may lead to the identification and development of a series of translational research projects. Results of these studies will provide vasculitis researchers with insight into the causes of these diseases and generate new ideas for diagnostic tests and therapies, and will be of great interest to the larger communities of researchers investigating vasculitis and other autoimmune, inflammatory, and vascular diseases.
Detailed description
Biopsy specimens collected as standard of care for these diseases will be retrieved and used in research. The most common biopsies performed are kidney, lung, skin, nerves, and vessels; however, other tissue is also of interest for the study. Biopsies are not performed as part of this protocol, rather we will request consent to collect biopsy specimens already collected under routine care.
Interventions
None listed
Sponsors
University of Pennsylvania
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
National Center for Advancing Translational Sciences (NCATS)
Office of Rare Diseases (ORD)
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* A participant will be deemed eligible for this study if the participant is/was enrolled in another one of the VCRC observational/longitudinal protocols (5502, 5503, 5504, 5505, 5506, 5507, 5563) and/or one of the VCRC interventional studies (5522, 5523, 5526, 5527, or 5562).
Exclusion criteria
* Inability to give informed consent (or their guardians in the case of children) and to sign the consent form. * Unwilling to allow the use of their tissue for research.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Identify genes that increase the risk of developing vasculitis | 1 year | Evaluating of clinical data and linked biopsy specimens to identify genes that increase the risk of developing vasculitis. |
Countries
Canada, United States
Contacts
CONTACTKatie Doyle
STUDY_CHAIRPeter A Merkel, MD, MPH
University of Pennsylvania
Outcome results
None listed