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Strength Training and Different Subtypes of Parkinson´s Disease

Effects of Progressive Resistance Exercise in Akinetic-rigid Parkinson's Disease Patients

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02966600
Enrollment
28
Registered
2016-11-17
Start date
2016-02-29
Completion date
2016-04-30
Last updated
2016-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson Disease

Brief summary

The aim of this randomized controlled trial was to assess the impact of progressive resistance exercise (PRE) in PD patients with akinesia and rigidity (AR-subtype). The investigators hypothesized the intervention would have a beneficial effect on the study outcomes.

Detailed description

Twenty-eight patients with PD AR-type of both sexes, were recruited for this trial. Each participant were assigned randomly to either intervention (N=13) or control (N=15) group. The intervention group participated in sixteen PRE training sessions for eight weeks: two sessions per week on non-consecutive days, sixty-seventy min each one. The control group followed their usual weekly physical activity routine. All patients underwent antrophometrical and neuromuscular function assessment (CoP measurements -primary outcomes- and the Ten-Meters Walk Test -TMWT- -secondary outcomes-). In addition, they were asked to provide ratings for the Spanish validated versions of the the Freezing of Gait Questionnaire (FOG-Q, 6-item version) -secondary outcomes-, the 39-item Parkinson ́s disease Questionnaire (PDQ39) -secondary outcomes- and the MDS-UPDRS -secondary outcomes-. Additionally, ratings of perceived exertion (RPE) (Borg \>6-20 scale) - secondary outcomes-, were recorded at the end of each PRE training session. Tests were carried out at three times: pre-test (before the training program), post-test (eight weeks after pre-tests, at the end of the training period), and four weeks after the post-test (re-test).

Interventions

The intervention group participated in sixteen PRE training sessions for eight weeks: two sessions per week on non-consecutive days, sixty-seventy min each one.

OTHERPhysical Activity

The control group followed its usual weekly physical activity routine

Sponsors

University of Oviedo
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Investigator)

Eligibility

Sex/Gender
ALL
Healthy volunteers
No

Inclusion criteria

* Diagnosed with PD AR-type and Hoehn and Yahr Scale 1-2, (H&Y) * Do not express any type of dementia * Able to stand for two min without assistance; * Able to walk ten metres without assistance.

Exclusion criteria

* To suffer a neurological disease other than PD. * Do not meet some of the inclusion criteria.

Design outcomes

Primary

MeasureTime frame
Static posturography through the centre of pressures measurements (CoP).Eight weeks

Secondary

MeasureTime frame
Gait.Eight weeks
Freezing of gait.Eight weeks
The Movement Disorders Society-Unified Parkinson ́s Disease Rating Scale. (MDS-UPDRS).Eight weeks
The patient- perceived quality of life.Eight weeks

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026