Acute-On-Chronic Liver Failure, Cirrhosis and Chronic Liver Disease
Conditions
Brief summary
Acute-on-chronic liver failure (ACLF) is an ailment with high incidence of multiorgan failure (MOF) and consequent mortality. Systemic inflammation and susceptibility to infection are characteristic pathophysiological features. Prostaglandin E2 (PGE2) could subdue systemic inflammation and alleviate liver injury in mice model. However, there are no studies evaluating PGE2 as a predictor of early mortality.This study is designed to investigate whether plasma PGE2 and its receptors are associated with development of MOF and predict short-term mortality in patients with acute-on-chronic liver failure. By the way, we will also measure several other potential predictive factors (C-reactive protein,severe hyponatremia, Second infections,Diabetes mellitus,High density lipoprotein,interleukin-10,serum bile acids,ferritin,the neutrophil to lymphocyte ratio,soluable urokinase plasminogen activator receptor,vWF-Ag levels and FVIII-to-PC ratios).
Interventions
DIAGNOSTIC_TESTplasma suPAR, PGE2 measurement. Other biomarkers were just recorded from clinical laboratory.
Sponsors
First Affiliated Hospital of Zhejiang University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Clinical diagnosis of acute-on-chronic liver failure according to Asian-Pacific Association for the Study of the Liver (APASL) diagnostic criteria
Exclusion criteria
* Hepatocellular carcinoma(HCC) * Portal vein thrombosis * Pregnancy * Human immunodeficiency virus (HIV) * Patients who had received immunomodulator,or cytotoxic/immunosuppressive therapy within at least the preceding 12 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| all cause mortality | 90 days |
| incidence of multiorgan failure | 90 days |
Outcome results
None listed