CRRT for Glutamate Elimination After Cardiac Arrest

Pilot Trial Concerning Glutamate Elimination With CRRT for Neurological Outcome After Cardiac Arrest

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02963298

Acronym

GCRRT

Enrollment

Registered

2016-11-15

Start date

2016-10-31

Completion date

2017-09-06

Last updated

2019-06-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Reperfusion Syndrome

Brief summary

Glutamate is known to be a mediator for apoptosis after brain hypoxia e.g. due to cardiac arrest. This pilot trial evaluates the possibility of elimination of Glutamate by CRRT after cardiac arrest.

Interventions

PROCEDUREContinuous renal replacement therapy

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* post cardiac arrest

Exclusion criteria

* hemodynamic instable * in-hospital cardiac arrest

Design outcomes

Primary

Measure	Time frame	Description
Glutamate blood concentration in intervention arm over the time	72 hours	Reduction of blood Glutamate concentration by renal replacement therapy

Secondary

Measure	Time frame
number of participants with abnormal outcome parameters	up to 14 days

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 1, 2026