Effects of Continuous Haemofiltration vs Intermittent Haemodialysis on Microcirculatory Parameters in Septic Shock

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02962700

Enrollment

100

Registered

2016-11-11

Start date

2016-01-31

Completion date

2018-12-31

Last updated

2016-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Septic Shock

Keywords

continuous haemofiltration, intermittent haemodialysis

Brief summary

The aim of the study was to investigate whether CVVH, in comparison to intermittent haemodialysis (IHD), is able to improve regional perfusion in septic shock patients studied by muscle microdialysis

Detailed description

A prospective, randomized, clinical study ,including septic shock patients with acute renal failure, aged over 16 years. Patients were randomized to receive either CVVH or IHD for renal replacement therapy. Intermittent haemodialysis was carried out during the first 4 h at day 1 and day 2 of the study period. Systemic haemodynamics and interstitial tissue concentrations of lactate, pyruvate, glucose and glycerol were obtained at baseline, 6, 12,18 and 24 hours after initiation of renal replacement by using muscle microdialysis.

Interventions

DEVICEmuscle microdialysis

Systemic haemodynamics and interstitial tissue concentrations of lactate, pyruvate, glucose and glycerol were obtained at baseline, 6, 12,18 and 24 hours after initiation of renal replacement by using muscle microdialysis.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SCREENING

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

16 Years to 90 Years

Healthy volunteers

Inclusion criteria

* septic shock

Exclusion criteria

Design outcomes

Primary

Measure	Time frame
changes in the concentration of glucose (mmol/l) in the extracellular fluid of the skeletal muscle using a microdialysis probe inserted into the quadriceps femoris muscle.	at baseline, 6, 12, 18, 24, 30, 36, 42 and 48 hours after initiation of renal replacement
changes in the concentration of lactate (mmol/l) in the extracellular fluid of the skeletal muscle using a microdialysis probe inserted into the quadriceps femoris muscle	at baseline, 6, 12, 18, 24, 30, 36, 42 and 48 hours after initiation of renal replacement
changes in the concentration of pyruvate (µmol/l) in the extracellular fluid of the skeletal muscle using a microdialysis probe inserted into the quadriceps femoris muscle	at baseline, 6, 12, 18, 24, 30, 36, 42 and 48 hours after initiation of renal replacement
changes in the concentration of glycerol (µmol/l) in the extracellular fluid of the skeletal muscle using a microdialysis probe inserted into the quadriceps femoris muscle	at baseline, 6, 12,18, 24, 30, 36, 42 and 48 hours after initiation of renal replacement

Secondary

Measure	Time frame
changes in heart rate	at baseline, 6, 12, 18, 24, 30, 36, 42 and 48 hours after initiation of renal replacement
changes in vasopressor support doses	at baseline, 6, 12, 18, 24, 30, 36, 42 and 48 hours after initiation of renal replacement
changes in mean arterial blood pressure	at baseline, 6, 12, 18, 24, 30, 36, 42 and 48 hours after initiation of renal replacement

Countries

Tunisia

Contacts

Primary Contactzied hajjej

hajjej_zied@hotmail.com20358907

Backup Contactmustapha ferjani

mustapha.ferjani@planet.tn98329256

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026