Bronchopleural Fistula
Conditions
Brief summary
Bronchopleural fistula (BF), an abnormal passage or communication between a bronchus and another part of the body, may develop when there are penetrating wounds of the thorax and after lung surgery. Without effective therapy, treatment of BF is a challenge, with a high rate of mortality and teratogenicity. The investigators will conduct endoscopic injection of umbilical cord mesenchymal stem cells to fistula, observe the recovery of bronchopleural fistula and systemic reactions, to investigate the application of umbilical cord mesenchymal stem cells in the treatment of bronchopleural fistula.
Interventions
BIOLOGICALUCMSC
UCMSC: umbilical cord mesenchymal stem cells 3-5\*10\^7/5 ml
Sponsors
Shanghai iCELL Biotechnology Co., Ltd, Shanghai, China
The Second Affiliated Hospital of Fujian Medical University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* diagnosed with bronchopleural fistula by imaging or bronchoscopic examination * typical symptom of bronchopleural fistula, such as fever, cough, purulent sputum, weight loss… * patients present compromised conditions, who can only accept a conservative treatment.
Exclusion criteria
* absolute contraindication of bronchoscopic examination and treatment * with previous treatment of cell therapy, including stem cells.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| closure of the fistula | 24 weeks | median time for fistula closure |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| complication | 1 year | fever, coughing up blood, infection... |
Countries
China
Contacts
Primary ContactYimin Zeng, Dr.
Outcome results
None listed