Different Anesthetic Managements of Esophageal Resection and Reconstruction

The Effects of Different Anesthetic Managements on Inflammation, Oxidative Injuries, and Major Organ Complications: a Prospective Investigations on Esophageal Reconstruction and Intraoperative Shock

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02961140

Enrollment

Registered

2016-11-10

Start date

2016-11-30

Completion date

2019-11-30

Last updated

2016-11-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia, Esophagus Cancer, Postoperative Complications

Keywords

Outcome

Brief summary

Anesthetic management and fluid therapy is crucial in esophageal resection and reconstruction, which is associated with high incidence of postoperative morbidity and mortality. This study aims to investigate the effect of goal directed fluid management on the postoperative outcome of esophageal resection and reconstruction.

Detailed description

Anesthetic management and fluid therapy is crucial in esophageal resection and reconstruction, which is associated with high incidence of postoperative morbidity and mortality. Excessive fluid administration may result in pulmonary complication, while extremely hypovolemia may lead to shock, circulatory dysfunction, and renal damage. Little is known about fluid status will have impact on anastomotic leakage. Goal-directed fluid therapy has shown to benefit perioperative outcome in major abdominal surgery. This study aims to investigate the effect of goal directed fluid management on the postoperative outcome of esophageal resection and reconstruction.

Interventions

OTHERCardiac Output Maximization

According to Frank-Starling law, the investigator will administer Voluven 6% 250 mL every 5 minute until stroke volume maximized (stabilized for 20 minutes), and maintain cardiac index and stroke volume variation during the whole operation.

OTHERCardiac Output Normalization

The investigator will administer intravenous fluids to keep cardiac index (CI) ≥ 2.2, and maintain CI and stroke volume variation during the whole operation.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

35 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Patients diagnosed as esophageal cancer * Scheduled for minimally invasive esophageal resection and reconstruction

Exclusion criteria

* End-stage organ dysfunction, including heart failure, hepatic failure, renal failure * Arrhythmia * Pregnancy

Design outcomes

Primary

Measure	Time frame	Description
Incidence of postoperative complication	1 month	Perioperative mortality, anastomotic leakage, pneumonia, respiratory failure, renal dysfunction, and surgical site infection

Secondary

Measure	Time frame	Description
Intraoperative hemodynamic stability	1 day	Incidence of intraoperative shock, use of vasopressor or inotropic agents
Length of stay	1 month	Intensive care unit length of stay and hospital stay

Contacts

Primary ContactYa-jung Cheng, M.D., Ph.D

chengyj@ntu.edu.tw+886-2-23123456

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026