Metabolome Analysis in Patients With Rheumatoid Arthritis

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02960958

Enrollment

200

Registered

2016-11-10

Start date

2016-11-20

Completion date

2019-10-31

Last updated

2018-01-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

RheumatoId Arthritis

Keywords

Rheumatoid arthritis, Metabolomics, urine

Brief summary

The aim of this study is to investigate discriminant metabolites in urine from patients with rheumatoid arthritis (RA) from healthy individuals. Then we determine if the patient's metabolic fingerprint could predict the development or flare-up of RA.

Detailed description

Compare metabolites between RA patients and healthy individuals. 1. Collection urine sample 2. Assessing urine metabolites by 1H NMR spectroscopy 3. Analyzing the relationships between metabolites and clinical variables

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* All patients with rheumatoid arthritis meet 2010 American College of Rheumatology/European League against Rheumatism classification criteria.

Exclusion criteria

* Comorbid with other autoimmune diseases * Confirmed with amyloidosis * Chronic kidney disease (estimated GFR \< 60 ml/min/1.73m2) * Chronic liver disease * Thyroid disease * Pregnancy * Solid tumor/hematologic malignancy within 5 years

Design outcomes

Primary

Measure	Time frame	Description
Metabolic fingerprint of rheumatoid arthritis	1 years	Metabolomic analyses of urine from patients with rheumatoid arthritis, healthy controls and other autoimmune disease

Secondary

Measure	Time frame	Description
Correlations between specific metabolites and disease activity/severity of RA	1 year	Identified metabolites and their clinical significances

Outcome results