Ohtahara Syndrome
Conditions
Brief summary
The current study examined the feasibility of High-Definition tDCS (HD-tDCS) in reducing epileptiform activity in a 30-month-old child suffering from early onset epileptic encephalopathy. HD-tDCS was administered over 10 intervention days spanning two weeks including pre- and post-intervention video-electroencephalography (EEG) monitoring.
Interventions
DEVICEHigh-definition (HD) transcranial direct current stimulator, HD-tDCS with 4x1 HD adaptor
Non-invasive focal neuromodulation
Sponsors
The City College of New York
Herzog Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
10 Months to 36 Months
Healthy volunteers
No
Inclusion criteria
1. Initial diagnosis of Ohtahara syndrome/West syndrome/ Lennox-Gastaut syndrome by a pediatric neurologist using video-EEG 2. Ongoing synchronous Hypsarrhythmia 3. Modified Hypsarrhythmia with a consistent focus of paroxysmal discharges 4. Signed informed consent of parents/immediate legal guardian 5. Age 10 to 36 months 6. Infant should be in a steady state indicated by a baseline test of electrolytes and biochemistry blood test, heart rate, temperature, respiratory rate, and saturation.
Exclusion criteria
1. Metal in the cranium, skull defects, or skin lesions on scalp (cuts, abrasions, rash) at proposed electrode sites. 2. History of adverse reaction to neurostimulation 3. Significant ECG abnormality
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change in seizure frequency from baseline | day 1, day 3, day 5, day 6, day 8, day 10, day 13, day 20, day 27, day 33, day 40, day 50 |
Countries
Israel
Outcome results
None listed