Hypertension
Conditions
Keywords
Dietary Potassium
Brief summary
The investigators aim to evaluate the acute effects of potassium supplementation achieved by ingestion of potassium rich food, on vascular health.
Detailed description
Many studies have shown that an increase in potassium through the diet or through potassium pills helps to lower blood pressure. Also, the amount of oral potassium taken can improve how well the participants blood vessels work. These studies have focused on potassium given in the form of a pill. The investigators are interested in the effect of potassium consumed through food sources and how it will effect arterial health and blood pressure. The world health organization (WHO) recommends a K⁺ intake of at least 3510 mg/day from food for adults, excluding those with impaired K⁺ excretion. In this study the investigators aim to provide approximately 75% (approximately 2000 mg) of the total daily recommended intake for potassium in one meal. The investigators do not know whether dietary potassium (not pill form) will acutely improve the arterial health and if it will cause a decrease in blood pressure. The investigators hypothesis to see an improvement in vascular function following a high potassium meal compared to a low potassium meal.
Interventions
OTHERHigh Potassium Meal
Breakfast meal that provides \ 2400 mg of dietary potassium. Meals are isocaloric.
OTHERLow Potassium Meal
Breakfast meal that provides \ 540 mg of potassium. Meals are isocaloric.
Sponsors
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* 18-80 years * Normal sinus rhythm * A diagnosis of hypertension on medical therapy with an ambulatory systolic blood pressure \<160 mmHg and diastolic blood pressure \<90 mmHg, or a diagnosis of stable coronary artery disease
Exclusion criteria
* Recent hospital admission due to an cardiovascular events * Serum K+ concentration \>5.0 mmol/L * Current smoking * Women who are pregnant * Diabetic patients - patients receiving insulin therapy * Glomerular filtration rate \< 90mls/min/1.73m2 * On loop diuretic therapy * Food allergies and/or intolerance to meal items
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Flow Mediated Dilatation | Flow Mediated Dilatation will be assessed over 2 clinic visits, at 3 times points with in each visit; pre-prandial and post-prandial at 60 min and 120 min | Flow Mediated Dilatation is a method used to measure endothelial-dependent regulation of conduit artery tone(Joannides R, 1995). |
Countries
Canada
Outcome results
None listed