Bronchial Fistula
Conditions
Brief summary
Bronchial fistula (BF), an abnormal passage or communication between a bronchus and another part of the body, may develop when there are penetrating wounds of the thorax and after lung surgery. Without effective therapy, treatment of BF is a challenge, with a high rate of mortality and teratogenicity. The investigators will conduct endoscopic injection of human amniotic epithelial cells to fistula, observe the recovery of bronchial fistula and systemic reactions, to investigate the application of human amniotic epithelial cells in the treatment of bronchial fistula.
Interventions
BIOLOGICALhAEC
hAEC: human amniotic epithelial cells
Sponsors
Shanghai iCELL Biotechnology Co., Ltd, Shanghai, China
The Second Affiliated Hospital of Fujian Medical University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosed with bronchial fistula by Imaging or bronchoscopic examination * typical symptom of bronchial fistula, such as fever, cough, purulent sputum, weight loss… * patients present compromised conditions, who can only accept a conservative treatment.
Exclusion criteria
* absolute contraindication of bronchoscopic examination and treatment * with previous treatment of cell therapy, including stem cells.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| median time for fistula closure | 12 weeks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| complication | 1 year | fever, coughing up blood, infection... |
Countries
China
Contacts
Primary ContactYimin Zeng, Dr.
Outcome results
None listed