Childhood Obesity, Childhood Onset Obesity, Pediatric Obesity
Conditions
Brief summary
In order to better understand early onset obesity and to identify patients in interested in future research studies, including clinical trials, we aim to develop a registry for patients with early onset obesity.
Detailed description
Obesity is an epidemic effecting the pediatric population. Currently, 17% of children are classified as obese and 32% as overweight. Many of these children develop complications including type 2 diabetes, dyslipidemia, hypertension and hepatic steatosis. Obesity is a global epidemic that lacks effective treatment options. Obesity has many underlying causes including genetic predisposition and environmental factors. Understanding the genetic basis of obesity may allow for more precisely targeted interventions including specific dietary plans and pharmacologic treatments. The most common cause of genetic obesity is haploinsufficiency of the melanocortin-4 receptor (MC4R). In obese adult cohorts, the prevalence of pathogenic MC4R mutations is 1-2%. Commercial testing is available for many obesity syndromes, but the cost is high and charges are not always covered by insurance. Clinicians have little motivation to test patients for MC4R mutations as no treatments are available and it is not clear if genetic testing results change patient behavior. This particular lab and other groups are working to develop novel pharmacologic treatments for obesity syndromes, such as MC4R deficiency. In order to better understand early onset obesity and to identify patients in interested in future research studies, including clinical trials, the investigators aim to develop a registry for patients with early onset obesity.
Interventions
None listed
Sponsors
Vanderbilt University Medical Center
Study design
Observational model
OTHER
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
2 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
1. BMI \>97th percentile for age and gender before 6 years old 2. Able to give written, informed consent/assent
Exclusion criteria
1. Diagnosis of Prader-Willi syndrome 2. Use of exogenous steroids or other medications known to cause abnormal weight gain 3. Cushing's syndrome, untreated growth hormone deficiency or untreated hypothyroidism as an etiology for the obesity 4. Hypothalamic obesity (obesity due to a brain tumor, head trauma or other brain lesion) 5. Currently pregnant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prevalence of genetic mutations in DNA analysis | 5 years |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORAshley Shoemaker, MD
Vanderbilt University Medical Center
Outcome results
None listed