Sepsis
Conditions
Keywords
sepsis, exosomes, dendritic cell
Brief summary
The amount of peripheral blood exosomes has been confirmed to change in the endotoxin-induced infection. The primary objectives of this study are to compare the changes of peripheral blood dendritic cell-derived exosomes in the patients with sepsis and the healthy controls.
Detailed description
This is a prospective, single-centered, clinical cohort study.
Interventions
DRUGAntibiotics
In the sepsis group, antibiotics were used when needed.
Sponsors
Jinling Hospital, China
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients were selected with the diagnostic standard Sepsis 3.0. * Healthy volunteers do not have serious illness.
Exclusion criteria
* Patients or volunteers do not agree to provide written informed consent and / or can not be legally authorized to provide informed consent. * Patients give up treatments. * Patients or volunteers withdrew from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amount of dendritic cell-derived exosomes | The first 4 hour after admission |
Secondary
| Measure | Time frame |
|---|---|
| Compositions of microRNA in the dendritic cell-derived exosomes | The first 4 hour after admission |
Countries
China
Contacts
Primary ContactJianan Ren, MD
Backup ContactYuan Li, MD
Outcome results
None listed