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Effect of Affordance of Objects on the Memory: Study in Transcranial Magnetic Stimulation

Effect of Affordance of Objects on the Memory: Study in Transcranial Magnetic Stimulation (SIMULANG-TMS)

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02956304
Acronym
SIMULANG-TMS
Enrollment
30
Registered
2016-11-07
Start date
2017-04-03
Completion date
2018-11-30
Last updated
2017-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Brief summary

The purpose of this study is determine the involvement of motor system in the memory of manipulable objects. The idea is to stimulate the ventral premotor cortex with transcranial magnetic stimulation to see whether this stimulation will affect memory of manipulable objects.

Detailed description

Embodied cognition claims that representations shares processing resources with sensorimotor systems. More specifically, it has been proposed that language comprehension relies on internal simulation of the meaning. For instance, numerous studies have shown that the processing of action-related concepts involve a motor activation similar to when the action is actually performed. However, even if those studies show clearly that action-related concepts involve a motor activation, such activations may be incidental to the activation of their representations, rather than part of it. Another way to show that this motor component takes part in the representation of manipulable objetcs is to investigate whether an impairment of motor system would impair the memory of manipulable object. In this study, investigators will use Transcranial Magnetic Stimulation (TMS) to stimulate ventral premotor cortex (PMv) to see whether this stimulation will affect memory of manipulable objects, but not memory of nonmanipulable objects. For this purpose, three TMS conditions will be assessed: cTBS to inhibit the motor cortex, iTBS to excite the motor cortex, and a SHAM condition as control.

Interventions

OTHERPMv stimulation (iTBS)

PMv stimulation (iTBS)

OTHERPMv inhibition (cTBS)

PMv inhibition (cTBS)

OTHERControl (SHAM)

Control (SHAM)

Sponsors

University of Paris 5 - Rene Descartes
CollaboratorOTHER
Centre Hospitalier St Anne
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes

Inclusion criteria

* 18 and 35 years * Right-handers (score between 70 and 100 on the scale of Edinburgh) * Native language : French * Not depressed (score lower than 14 in the BDI) * health insurance * Consent

Exclusion criteria

* Psychiatric family history up to the second degree * Medical treatment, in particular psychotropic being able to affect the memory and the attention * view or hearing disorders (not compensated) * neurological histories (epilepsy, alcoholism in particular) or psychiatric or important memory complaints * Contraindications for the SMT * contraindications in the MRI

Design outcomes

Primary

MeasureTime frameDescription
Number of objects affordants and of objects not - affordants reminded1 weekMeasure of the number of objects affordants and of objects not - affordants reminded according to if the stimulation is in PMv or control

Secondary

MeasureTime frameDescription
Number of object reminded1 weekMeasure of the number of objects affordants and of objects not - affordants reminded according to if the stimulation is excitation or control

Countries

France

Contacts

Primary ContactBenoit CREPON, MD
b.crepon@ch-sainte-anne.fr00 33 1 45 65 87 70
Backup ContactMarie GODARD
marie.godard@aphp.fr00 33 1 45 65 77 28

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026