Acute Renal Insufficiency
Conditions
Keywords
acute renal insufficiency, Iodinated Contrast Agents, pediatric
Brief summary
Iodinated contrast media are now frequently used in diagnostic imaging exams, including pediatrics. In adults, the acute renal failure (ARF) associated with contrast agents (CA-AKI) occur in 3-33% of exposed patients, especially as the patient is fragile, has comorbidities or pre-existing renal aggression . In children, the prevalence of this little known disease is probably underestimated. The investigators intend to conduct a prospective epidemiological study, to estimate the impact of the acute renale failure to iodinated contrast agents in pediatrics.
Detailed description
Patients will be included those of pediatric emergencies, Hospitalization Unit of Short Duration pediatric, pediatric intensive care and pediatric resuscitation. The acute renale failure will be estimated on the basis of criteria KDIGO (score of kidney disease) group in 2012 to 48 hours a computed tomography (CT) scan with injection of contrast media, based on a change in creatinine clearance of the estimated according to the formula Schwartz revised in 2009 and / or diuresis. Patient characteristics will be identified in order to establish risk factors.
Interventions
OTHERCT scan with iodinated contrast agents
Before the CT scan, the investigators with iodinated contrast agents, the following data will be collected in the medical record: creatinine prior to injection, comorbidities and child characteristics, associated treatments and risk factors of acute renal failure, as well as the injection pattern. After the CT scan the investigators will collect the characteristics of the injection type, osmolarity and volume of contrast used and the appearance of a possible allergic reaction. Then 24 and 48 hours and day 7 will collect serum creatinine, urine output and vital replacement therapies may be necessary.
Sponsors
Centre Hospitalier Universitaire de Saint Etienne
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 16 Years
Healthy volunteers
No
Inclusion criteria
* Patients under 16 years admitted to a participating service * Patient receiving an injected CT scan
Exclusion criteria
* Prior Inclusion in the study during an earlier review. * Opposition of parents. * Chronic renal failure or end-stage requiring renal replacement in the long term.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Creatinine | change from baseline creatinine at 7 days | data gathered in the medical file |
| Diuresis | change from baseline diuresis at 7 days | data gathered in the medical file |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Readmission | at 7 days | Number of patients with no or having an adverse event during the readmission. |
| Hospitalization in intensive care | at 7 days | Number of patients with no or having an adverse event during the hospitalization in intensive care. |
| Renal replacement | at 7 days | Number of patients with no or having an adverse event during the renal replacement. |
| Death | at 7 days | Number of dead |
Countries
France
Outcome results
None listed