Low Back Pain
Conditions
Brief summary
Patients with inflammatory back pain were shown to differ from healthy controls in genotype of the Angiotensin-converting enzyme (ACE), which regulates vasoconstriction/-dilatation. The aim of this study is to investigate whether genetic reduction of muscle perfusion might be a pathophysiological pathway of how genes influence chronic non-specific low back pain (LBP).
Detailed description
The following genes will be investigated: * Insertions-/deletions-polymorphism of the angiotensin-converting enzyme (ACE-I/D gene polymorphism; 3 genotypes: ACE-II, ACE-ID, ACE-DD). * Anti-adhesive extracellular matrix protein Tenascin-C: gene polymorphism rs2104772 The goals of this study are to investigate whether these genotypes correlate with 1) endurance of back muscles, 2) comorbidities such as asthma and diabetes and 3) the risk for LBP as assessed by a LBP-classification tool.
Interventions
OTHERno intervention
observational case-control study
Sponsors
Balgrist University Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* 18-65
Exclusion criteria
* Spinal surgery * Spinal fracture * Inflammation * Tumour * Severe chronic disease which make intensive physical activity impossible (osteoporosis, cardiovascular heart diseases)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Polymorphism ACE Gene | baseline |
| Polymorphism Tenascin Gene | baseline |
Secondary
| Measure | Time frame |
|---|---|
| Back muscle endurance in Sorensen test | baseline |
Countries
Switzerland
Outcome results
None listed