Chronic Periodontitis, Polycystic Ovary Syndrome
Conditions
Keywords
8- hydroxy -2´- deoxyguanosine, Malondialdehyde, Total antioxidant status, Oxidative stres
Brief summary
Background: The aim of this study was to investigate the levels of malondialdehyde (MDA), total antioxidant status (TAS), 8-hydroxy-2´- deoxyguanosine (8-OHdG) in blood serum and saliva samples in female patients with chronic periodontitis (CP) and to compared healthy individuals. Materials and Methods: A total of 88 women were into four groups each which were consisted of twenty-two subjects. Groups were designed as periodontally and systemically healthy women (PCOS-CP-); periodontally healthy women with polycystic ovary syndrome (PCOS) (PCOS+CP-), systemically healthy women with CP (PCOS-,CP+) and women with PCOS and CP (PCOS+CP+). Serum and salivary samples were obtained, clinical periodontal parameters were recorded. MDA, TAS, 8-OHdG levels were measured as biochemically.
Detailed description
RESULTS: Salivary 8-OHdG levels in the PCOSCP and CP groups were statistically higher than those in both the PCOSPH and the PH groups (P \< 0.05). There was no statistical difference between the PCOSCP, CP, and PCOSPH groups with regard to salivary MDA and TAS levels (P \> 0.05). Highest serum 8-OHdG and MDA levels and lowest serum TAS levels were seen in the PCOSCP group (P \< 0.05). Serum 8-OHdG and MDA levels in the PCOSPH group were higher than those in both systemically healthy groups (PH and CP) (P \< 0.05). Salivary TAS levels were highest (P \< 0.05) in the PH group. There was no statistical difference between the CP and PCOSPH groups, but serum TAS levels were lower than those in the PH group (P \< 0.05). CONCLUSIONS: CP, which led to an increase in serum and salivary 8-OHdG and MDA levels and a decrease in serum TAS levels in patients with PCOS, contributed to increased OS. This effect was more prominent in serum levels than in salivary levels.
Interventions
Sponsors
Bezmialem Vakif University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Newly diagnosed non-obese PCOS patients * Never smokers * Had no history of systemic disease * BMI\<25 kg/m2 * Participants had ≥20 teeth present.
Exclusion criteria
* Pregnancy * Lactation * Hemoglobin A1c (HbA1c) ≥ 6.5% * 2-h oral glucose tolerance test (OGTT-2h) ≥200 * Cushing syndrome, non-classic congenital adrenal hyperplasia, hyperprolactinemia, thyroid dysfunction, and androgen-secreting tumors * Any drug use within the past 6 months * Periodontal treatment within the past 6 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Probing pocket depth (PD)) | appoximately 2 years | distance between free gingival margin and periodontal pocket base by usin periodontal probe |
| Bleeding on probing (BOP) | appoximately 2 years | Gİngival Bleeding Index |
| Clinical attachment level (CAL) | Patients were seen one time | by measuring the distance between the cementoenamel junction and the periodontal pocket base |
| 8-OHdG levels (nanogram per mililiter(ng/mL)) | appoximately 2 years | by ELISA test |
| MDA levels (micromole per liter (µmol/L)) | appoximately 2 years | by ELISA test |
| TAS levels (millimolar per liter (mmol /L)) | appoximately 2 years | by ELISA test |
| Plaque Index (PI) | appoximately 2 years | Silnes-Löe Periodondal İndex |
| Gingival Index (GI) | appoximately 2 years | Löe-Silness Periodontal Index |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| numberer of individuals with polycystic ovary syndrome | appoximately 2 years | individuals in the group |
| number of individuals with chronic periodontitis | appoximately 2 years | individuals in the group |
Countries
Turkey (Türkiye)
Outcome results
None listed