Metabolic Disease, Overweight and Obesity, Sedentary Lifestyle
Conditions
Keywords
Exercise, Breaking prolonged sitting, physical activity
Brief summary
The primary aim of this study is to investigate the acute effect of the frequency and duration of breaks in sitting time on the metabolic risk factor profile.
Detailed description
Fifteen (n=15) sedentary adult overweight males will be included in the study. All participants will undergo the four interventions in a randomized cross-over design. Wash out between intervention will be minimum four days. Control (CON): Participants will be sedentary. Sedentary time will be spent sitting in a chair, restricted to sedentary behaviors (working on a computer, reading, watching TV, etc.), with a target MET below 1.5 (i.e. 1.5 times REE). Participants will only be allowed to stand or walk to go to the toilet. Breaker: Participants will be breaking up prolonged sitting with 2 min intervals of low intensity walking. Intermediate: Participants will be breaking up prolonged sitting with 6 min intervals of low intensity walking Prolonger: Participants will be breaking up prolonged sitting with 12 min intervals of low intensity walking All interventions will be matched for total physical activity as well as sitting. Thus, we aim for the active interventions to be iso-caloric.
Interventions
BEHAVIORALControl
Control intervention
BEHAVIORALBreaker
Short breaks of physical activity
BEHAVIORALProlonger
longer breaks of physical activity
BEHAVIORALIntermediate
Intermediate breaks of physical activity
Sponsors
Rigshospitalet, Denmark
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
20 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Males, age 20-50 years, waist-to-height ratio ≥ 0.5 and/or waist circumference ≥ 102 cm.
Exclusion criteria
* Clinically diagnosed diabetes, uncontrolled hypertension, use of glucose- and/or lipid-lowering medication, smoking, evidence of thyroid, liver, lung, heart or kidney disease, non-sedentary occupation, and VO2max levels above the considered average fitness according to age (Shvartz & Reibold 1990), contraindications to increased levels of physical activity.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AUC post prandial glucose concentration | 6 hours |
Secondary
| Measure | Time frame |
|---|---|
| AUC post prandial insulin concentration | 6 hours |
| AUC post prandial c-peptide concentration | 6 hours |
| AUC post prandial triglyceride concentration | 6 hours |
| AUC post prandial total cholesterol concentration | 6 hours |
| AUC post prandial ldl concentration | 6 hours |
| AUC post prandial hdl concentration | 6 hours |
| AUC post prandial glucagon concentration | 6 hours |
| Mean 24 hour glucose concentration | 24 hours |
| Variation in 24 hour glucose concentration | 24 hours |
| Maximum in 24 hour glucose concentration | 24 hours |
Countries
Denmark
Outcome results
None listed