Renal Transplant
Conditions
Keywords
Arterial stiffness, Klotho-FGF23
Brief summary
The primary objective is to show that the contribution of Klotho by the renal graft is an independent determinant of the evolution of the recipient's central arterial stiffness during the first year of renal transplant. The contribution of Klotho by the graft will be estimated by: its circulating concentrations assay, its urinary excretion assay, and, indirectly, by the circulating concentrations of FGF23. The recipient's central arterial stiffness will be estimated by the measure of the carotid-femoral pulse wave velocity, noninvasive reference method for measuring aortic stiffness in human.
Interventions
BIOLOGICALBiological sample
PROCEDURENon invasive Arterial investigations
PROCEDUREAbdominal tomodensitometry
Sponsors
Hopital Foch
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Man or woman 18 to 70 years old * Renal transplant * Dead donor or alive donor * Immunosuppression including a calcineurin inhibitor * Written consent
Exclusion criteria
* MultipleTransplant * Morbid Obesity (Body Mass Index (BMI)\> 40 kg/m2 sc) * Cardiac Arrhythmia * Lower limbs occlusive arterial disease * Impossibility to understand the information form
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Carotid-femoral pulse wave velocity | 12 months |
Secondary
| Measure | Time frame |
|---|---|
| Carotid intima-media thickness | 12 months |
| Endothelial function | 12 months |
| Arterial calcification | 12 months |
| Sectional carotid stiffness | 12 months |
| Klotho concentration | 1 day |
| FGF23 concentration | 1 day |
| Pulsed central veinous pressure | 12 months |
Countries
France
Outcome results
None listed