Change in Serum Chloride Level
Conditions
Keywords
sterofundin, resuscitation, normal saline, chloride, fluid, SID, pH, osmolality, urine
Brief summary
Prospective, crossover, randomized trial to evaluate plasma compositions after loading dose of sterofundin solution given to healthy volunteer in the resuscitation manner compared with normal saline solution.
Detailed description
10 healthy volunteers were randomly assigned to receive either normal saline or sterofundin for the first solution in dose of 30 mL/kg (max 2 L) over 1 hour. Blood was collected at baseline (T0), at 60 minutes (T1), 120 minutes (T2), and 240 minutes (T4) from baseline. Time to fist void after initiation of fluid and urine volume were also recorded. After wash-out period of at least 1 week, crossover studies were performed with another fluid.
Interventions
DRUGSterofundin
Fluid loading
DRUGNSS
Fluid loading
Sponsors
Ramathibodi Hospital
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* No underlying disease * LVEF \> 0.5 * No current medication usage
Exclusion criteria
* Pregnancy or lactation * BMI \<18 or \>25 * Fever presented in the past 2 weeks
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in serum chloride | 4 hours | At 0, 1, 2, and 4 hours from initiation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in serum pH | 4 hours | At 0, 1, 2, and 4 hours from initiation |
| Change in serum osmolality | 4 hours | At 0, 1, 2, and 4 hours from initiation |
| Change in serum SID | 4 hours | At 0, 1, 2, and 4 hours from initiation |
| Time to first void | Within 24 hours | Time in minutes from initiation of fluid to first urination |
| Urine volume | Within 24 hours | Volume of first urination in ml |
Outcome results
None listed