Effect of Yoga on Mood and Quality of Life in Patients With Refractory Epilepsy

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02950636

Enrollment

Registered

2016-11-01

Start date

2016-12-31

Completion date

2017-10-04

Last updated

2018-04-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anxiety, Depression

Keywords

Epilepsy

Brief summary

The purpose of this study is to learn if a structured yoga program can reduce anxiety, improve depression, and improve quality of life in patients with medication resistant epilepsy (MRE).

Interventions

OTHERYoga

Restorative Yoga

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Diagnosis of unilateral or bilateral temporal lobe epilepsy * Presence 3 or more seizures per month * No medical contraindications to yoga * Willing and able to perform simple non strenuous yoga exercises * Ability to get on the floor and up again without assistance * Ambulatory * Ability to travel to the yoga class twice a week

Exclusion criteria

* Any yoga in the last 6 months * Inability to perform yoga exercises * History of epilepsy surgery within the last year * Currently pregnant or less than 6 week postpartum

Design outcomes

Primary

Measure	Time frame	Description
Change in Neurological Disorders Depression Inventory for Epilepsy (NDDI-E)	Change from Week 4 to Week 12	The NDDI-E is a 6 item questionnaire. Scores for each question range from 1 (never) to 4 (all the time). There is a maximum score of 24. The higher the score the more severe the depression.

Secondary

Measure	Time frame	Description
Change in Generalized Anxiety Disorder 7-item (GAD-7) scale	Change from Week 4 to Week 12	The GAD-7 is a 7 item questionnaire. Scores for each question range from 0 (not at all) to 3 (nearly every day). There is a maximum score of 21. The higher the score the more severe the anxiety. A score over 15 represents severe anxiety. A score under 10 may indicate GAD and would prompt further examination.
Change in Quality of Life in Epilepsy-Patient-Weighted (QOLIE-31-p)	Change from Baseline to Week 12	The QOLIE-31-p is a 38 item questionnaire. Scores range from 0-100. Higher scores relate to higher distress.
Frequency of seizures	Week 12	Count of seizures in study subjects

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026