Multiple Sclerosis, Progressive
Conditions
Keywords
Progressive Multiple Sclerosis, Rehabilitation, Exercise
Brief summary
This is a pilot trial to explore the cardiovascular of eight weeks of twice weekly high intensity interval training in people with progressive multiple sclerosis. A control group of people with progressive multiple sclerosis will undergo continuous moderate intensity exercise, twice weekly for 8 weeks.
Detailed description
This is a pilot trial to explore the cardiovascular of eight weeks of twice weekly high intensity interval training in people with progressive multiple sclerosis. A control group of people with progressive multiple sclerosis will undergo continuous moderate intensity exercise, twice weekly for 8 weeks. The training program will entail 6x1.5 minute intervals working at 80-95% heart rate max on a cycle ergometer. Each interval will be interspersed with 1.5 minutes of working rest at a light resistance of the participant's choosing. The continuous moderate intensity exercise program will entail 20 minutes on a cycle ergometer working at 60-70% heart rate max.
Interventions
OTHERHigh intensity interval training
1.5 min intervals at 80-95% heart rate max on cycle ergometer 1.5 min intervals at nominal resistance on cycle ergometer
20 min at 60-70% heart rate max on cycle ergometer
Sponsors
NHS Ayrshire and Arran
AKM
University of Glasgow
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Diagnosed with a progressive form of MS * Aged 18 years or older * Known to members of staff of the MS service NHS Ayrshire & Arran * Ability to attend Douglas Grant Rehabilitation centre twice a week for eight weeks * EDSS 4-6.0 * Able to cycle on ergometer
Exclusion criteria
* A relapse of symptoms requiring treatment within the past three months. * A respiratory condition that would be exacerbated by high intensity exercise including but not limited to: chronic obstructive pulmonary disorder, uncontrolled or poorly controlled asthma. * Uncontrolled high pressure at screening (\>190/100 mmHg) * Cognitive impairment affecting ability to understand instructions as noted in patient's notes. * Currently engaging in another research trial for their MS or that may affect their physiological or cardiovascular outcomes * Weighing more than 110 kg (weight limit of ergometer) * Any pathology or medical intervention that would preclude high intensity exercise, maximal exertion testing or could attenuate the cardiovascular effect of exercise including but not limited to: unstable angina; diabetes; peripheral vascular disease or intermittent claudication; having a pace maker or medicine pump; surgical clips; having another neurological condition other than MS; and pregnancy. To be established from patient's notes and at screening session. * A serious cardiovascular event in the past year including but not limited to: transient ischaemic attack, cerebrovascular event and myocardial infarction. * Taking any of the following medication: beta blockers; vasodilators; ACE inhibitors; diuretics or any other medication that could cause exercise induced hypotension; hypoglycaemic insulin; metformin or other oral insulin medicine.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| heart rate max | 8 weeks | Maximal heart rate elicited during a maximal exertion test |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Resting heart rate | 8 weeks | — |
| Brain derived neurotrophic factor | 8 weeks | Hormone important for brain growth and protection |
| Lactate | 8 weeks | Waste materials from exercise in blood |
| Lipoprotein profile | 8 weeks | Indication of how much good and how much bad cholesterol is in blood |
| Resting blood pressure | 8 weeks | — |
| Hospital anxiety and depression scale | 8 weeks | Questionnaire giving a score of depression and anxiety |
| Timed 25 foot walk test | 8 weeks | Measure of walking speed |
| Symbol digit modalities test | 8 weeks | Measure of mental processing speed |
| Fatigue severity scale | 8 weeks | Questionnaire which gives measure of fatigue. |
| MSIS-29 version 2 | 8 weeks | Questionnaire giving physical and psychological impact of MS |
Countries
United Kingdom
Outcome results
None listed