Prevention of Type 2 Diabetes Amongst South Asians With Central Obesity and Prediabetes

Conditions

Type 2 Diabetes

Brief summary

The investigators' general goal is to identify approaches to risk stratification and health promotion through lifestyle modification that are acceptable, effective and efficient for prevention of T2D in South Asian communities from diverse settings.

Detailed description

The specific aims of the proposed iHealth-T2D study are: 1. Determine whether intensive lifestyle modification vs usual care reduces risk of T2D (primary endpoint) amongst South Asians with i. central obesity; ii. prediabetes and iii. overall (with central obesity and / or obesity). 2. Investigate secondary endpoints, including health gains in family members. Identify social, demographic and environmental factors influencing primary and secondary endpoints. 3. Carry out a health economic analysis of lifestyle modifications vs usual care for prevention of T2D on the Indian subcontinent and Europe. Quantify the cost-effectiveness of screening by waist circumference vs HbA1c.

Mirthe Muilwijk, Marie Loh, Sara Mahmood, Saranya Palaniswamy, Samreen Siddiqui et al. (19 authors)

Trials2022-09-063 citations

10.1186/s13063-022-06667-1

The iHealth-T2D study, prevention of type 2 diabetes amongst South Asians with central obesity and prediabetes: study protocol for a randomised controlled trial.

Kasturiratne A, Khawaja KI, Ahmad S, Siddiqui S, Shahzad K, Athauda LK, Jayawardena R, Mahmood S, Muilwijk M, Batool T, Burney S, Glover M, Palaniswamy S, Bamunuarachchi V, Panda M, Madawanarachchi S, Rai B, Sattar I, Silva W, Waghdhare S, Jarvelin MR, Rannan-Eliya RP, Gage HM, van Valkengoed IGM, Valabhji J, Frost GS, Loh M, Wickremasinghe AR, Kooner JS, Katulanda P, Jha S, Chambers JC.

2021-12-185 citations

10.1186/s13063-021-05803-7

Effects of a lifestyle intervention programme after 1 year of follow-up among South Asians at high risk of type 2 diabetes: a cluster randomised controlled trial

Mirthe Muilwijk, Marie Loh, Samreen Siddiqui, Sara Mahmood, Saranya Palaniswamy et al. (33 authors)

BMJ Global Health2021-11-0113 citations

10.1136/bmjgh-2021-006479

Papers published before 2008-02-04 may not appear yet. Historical indexing is in progress.

Interventions

BEHAVIORALIntensive lifestyle modification

The intervention is delivered as 9 face-face and 13 telephone contact sessions over 12 months. Index cases are the focus for the intervention, but lifestyle modification encourages the whole family to adopt healthy living.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

SINGLE (Investigator)

Eligibility

Sex/Gender

ALL

Age

40 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* Waist circumference≥100cm OR HbA1c≥6.0% * South Asian, Male or Female, and age 40-70 years

Exclusion criteria

* Known type 1 or 2 diabetes * Fasting glucose≥7.0 mmol/L or HbA1c ≥6.5% * Normal or underweight (body mass index\<22kg/m2) * Pregnant or planning pregnancy * Unstable residence or planning to leave the area * Serious illness * Lack of capacity to consent

Design outcomes

Primary

Measure	Time frame	Description
>7% reduction in weight	4 year	The investigators aim to achieve this outcome by motivating study participants to improve diet habits and increase physical activity

Secondary

Measure	Time frame	Description
Reduction of ≥5 cm waist circumference	4 year	The investigators aim to motivate the participants to adopt a healthier lifestyle in order to achieve at least 5cm waist circumference reduction

Countries

United Kingdom

Outcome results

None listed