Liver Cirrhosis, Liver Dysfunction
Conditions
Keywords
Prehabilitation, liver transplant, functional capacity, exercise
Brief summary
A UK prospective, single-centre feasibility study investigating the effects of exercise therapy on functional capacity in patients on the waiting list for liver transplantation. Patients will receive a 12-week home prehabilitation program (daily step program; functional resistance exercise sessions; telephone health call or virtual clinic). The following will be assessed at weeks 0, 6 and 12 weeks: feasibility (recruitment, compliance, safety, patients perception), functional capacity (ISWT, SPBT), psychological wellbeing (HADS questionnaire) and quality of life (EQ-5D)
Detailed description
as above
Interventions
BEHAVIORALHome prehabilitation program
12-week exercise therapy using daily step program (accelerometer), functional resistance exercise sessions and telephone/virtual clinic appointments
Sponsors
Queen Elizabeth Hospital NHS Foundation Trust
Matthew Armstrong
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Meet the United Kingdom Liver Transplant criteria for listing * Accepted on the liver transplant waiting list for a primary transplant * Adults ≥18years who have an indication for a liver transplant * Diagnosed with sarcopenia at liver transplant assessment
Exclusion criteria
* Significant cardiovascular instability including a recent Myocardial infarction, recent Cerebrovascular accident and/or a recent unstable arrhythmia * Unstable encephalopathy - open to interpretation by the chief investigator * Patient or next of kin non-English speaking * Inpatients * Refusal or lacks capacity to give informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants with intervention-related adverse events as assessed by CTCAE v4.0 | 12-week | As this is a feasibility/Pilot study the investigators need to assess if any participants have any adverse events related to the home prehabilitation programme and if so, determine the severity and frequency |
Other
| Measure | Time frame | Description |
|---|---|---|
| Functional capacity - incremental shuttle walk test | 12-weeks | incremental shuttle walk test |
| Functional capacity - short performance battery test | 12-weeks | — |
| Psychological wellbeing - HADS questionnaire | 12-weeks | HADS questionnaire |
| Quality of Life - EQ-5D questionnaire | 12-weeks | EQ-5D questionnaire |
Countries
United Kingdom
Outcome results
None listed