Urinary Stone
Conditions
Keywords
children, renal stone, metabolic evaluation, Mutational analysis
Brief summary
The incidence of nephrolithiasis in children has been reported to increase by approximately 6-10% annually, and the incidence is currently 50 per 100,000 children with high recurrent rate. Investigators aimed to determine the metabolic risk factors in Chinese children through metabolic evaluation. In order to identify diagnostic criteria of hypocitraturia and hyperoxaluria in western country wether adapt to Chinese children, investigators aim to determine normal urine levels of oxalate and citrate in children without kidney stone.
Detailed description
Investigators aimed to determine the metabolic risk factors in 200 Chinese children with urinary stones through metabolic evaluation. In order to identify diagnostic criteria of hypocitraturia and hyperoxaluria in western country wether adapt to Chinese children, investigators aim to determine normal urine levels of oxalate and citrate in children without kidney stone.
Interventions
OTHERurinary stone
patients of group one have urinary stones
Sponsors
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Years to 16 Years
Healthy volunteers
Yes
Inclusion criteria
* Children with urinary stones
Exclusion criteria
* Anatomic urinary system abnormality, vesicoureteral reflux, urinary tract infection (temperature \>38°C and/or positive urine culture), solitary kidney, and renal insufficiency
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Urinary oxalate; | urine collected in 24 hours |
Secondary
| Measure | Time frame |
|---|---|
| Urinary citrate; | urine collected in 24 hours |
| Urinary calcium | urine collected in 24 hours |
Countries
China
Contacts
Primary ContactHongquan Geng, M.D
Backup ContactLei He, M.D
Outcome results
None listed