Obesity
Conditions
Brief summary
The purpose of the research is to test whether a gymnemic acids (GA) lozenge will reduce reward region response to intake of high-sugar food and ad lib candy intake and whether the GA lozenge reduced reward region response to anticipated intake of high-sugar food and high-sugar food pictures relative to a placebo lozenge.
Detailed description
Test the hypothesis that an acute dose of Crave Crush will produce greater reductions in reward region response to a taste of a high-sugar/high-fat beverage and anticipated receipt of this beverage than a placebo dose. Test the hypothesis that a dose of Crave Crush will result in reduced ad lib candy intake while the participants complete a survey after the fMRI scan. Participants will receive a second dose of Crave Crush or placebo. They will then be placed in a room to complete a few surveys. A bowl of candy will be placed on the table. Participants will be told that the candy is left over from their assessment and that they are free to have as much as they like, because the candy must be discarded after each participant.
Interventions
DIETARY_SUPPLEMENTCrave Crush
Crave Crush is a dietary supplement that affects sweet taste receptors on the tongue.
DIETARY_SUPPLEMENTPlacebo
The placebo tablet is comparable in taste and is comprised primarily of sorbitol.
Sponsors
Cravecrush
Oregon Behavioral Intervention Strategies, Inc.
Oregon Research Behavioral Intervention Strategies, Inc.
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Between 18 and 50 years old * report having a sweet tooth * report desire to lose weight * Body Mass Index between 18 and 40
Exclusion criteria
* major psychiatric disorders * serious health problems (e.g., diabetes) * habitual use of psychoactive drugs or medications * contraindications for MRI scanning (e.g., ferromagnetic braces) * gluten or lactose intolerance * a vegan diet.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| fMRI responses to high-sugar food tastes and food cues | 13 minutes | Blood oxygen dependent signal (BOLD) response in exposure to intake of high-sugar food and food cues will be measured during a fMRI scan to test whether the GA lozenge produces greater reductions in activity in reward-related brain regions relative to a placebo lozenge. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| candy consumption | 15 minutes | The current study tested whether the GA lozenge reduces ad lib candy intake relative to a placebo lozenge. |
Outcome results
None listed