Clinical Application of Cross-education During Stroke Rehabilitation

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02948725

Acronym

X-Ed-Stroke01

Enrollment

Registered

2016-10-28

Start date

2016-11-30

Completion date

2022-12-31

Last updated

2023-05-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Brief summary

Based on the current state of knowledge and gaps in the literature we will conduct an intervention study to explore novel treatment and rehabilitation of patients at Royal University Hospital (RUH) with motor deficits following stroke. This project has the following objectives: 1. To determine if cross-education, in addition to standard rehabilitation leads to better recovery of upper limb function for stroke patients with hemiparesis. 2. To incorporate functional brain activation as measured by functional magnetic resonance imaging (fMRI) to examine the neural mechanisms associated with changes in motor function of the paretic arm post-stroke. 3. To use diffusion tensor imaging (DTI) tractography to measure connectivity and examine the extent to which white matter tract thickness correlates with preserved motor output in patients post-stroke.

Interventions

OTHERCross-education + standard rehabilitation

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* 18 years or older * within 18 months of stroke recovery * medically stable * ambulatory * have moderate to severe upper limb hemiparesis as diagnosed by clinicians * Consent

Exclusion criteria

* significant cognitive impairment or aphasia affecting understanding, as assessed by clinician * severe upper limb spasticity preventing any movement of the proximal arm and shoulder * diagnosis of hemorrhagic or bilateral stroke * history of other severe upper limb musculoskeletal injury * other neurological diseases * intracranial metal clips or cardiac pacemaker, or anything that would preclude an MRI * Any condition that would preclude the participant's ability to attend follow-up visits in the opinion of the Investigator

Design outcomes

Primary

Measure	Time frame
Motor function scores as assessed using the Fugl-Meyer Assessment	At 26 weeks

Secondary

Measure	Time frame
grip and wrist strength	At 26 weeks
volume of motor cortex activation	At 26 weeks

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026