Cerebral Infarct
Conditions
Keywords
Neutrophil Extracellular Traps
Brief summary
Cerebral infarcts represent a major cause of morbidity/mortality in spite of therapeutics for a premature recanalisation (intravenous recombinant tissue plasminogen activator (rt-PA) and thrombectomy). Thrombolysis failure by the administration of rt-PA is frequent, in particular in proximal occlusion. Experimental studies suggest that neutrophils could play an important role in the thrombus development via the organization of a network (NET) within the thrombus. Targeting this network of NET could, in addition to the fibrinolysis, increase the rate of recanalisation and thus improve the neurological prognostic after a cerebral infarct. The aim of the research is to Study of the biochemical and histological composition of the stemming thrombi of cerebral thrombectomies with in vitro analysis of the sensibility in the thrombolysis induced by rt-PA +/- Desoxyribonuclease I (DNase I).
Interventions
None listed
Sponsors
Hopital Foch
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient over 18 * Having a cerebral infarct consecutive to a wide calibre arterial occlusion * taken care for mechanical thrombectomy
Exclusion criteria
* Patient benefiting from a legal protective measure * Pregnant or breast-feeding woman * Opposition of the patient to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Correlation coefficient between biochemical and histological composition of the thrombus and the sensibility in the in vitro fibrinolysis and the origin of the thrombus. | 1 day |
Countries
France
Outcome results
None listed