Single Versus Multiple Visits Endodontic Treatment

Healing Rates After Single Versus Multiple Visits Endodontic Treatment of Necrotic Teeth With Apical Periodontitis: A Randomized Clinical Trial

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02947763

Enrollment

Registered

2016-10-28

Start date

2016-11-30

Completion date

2018-02-28

Last updated

2019-07-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periapical Periodontitis

Brief summary

Healing rate after single visit or multiple visit endodontic treatment using triple paste intracanal medicament will be assessed both clinically and radio-graphically for follow-up period up to one year

Detailed description

Patients with necrotic teeth with apical periodontitis will be selected according to the eligibility criteria and patients are then randomized to either single visit or multiple visit using triple paste intracanal medicament. Postoperative pain will then assessed using numerical rating scale after 1, 2, 3 and 7 days post-instrumentation. Radiographic healing will be assessed every 3 months up to one year.

Interventions

DRUGmixture of metronidazole, ciprofloxacin, and minocycline

placement of intracanal medication

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

16 Years to 55 Years

Healthy volunteers

Inclusion criteria

1. Adult patients; age between 16-55 years old. 2. Males or Females. 3. Maxillary or mandibular single-root tooth or a multi-rooted tooth with: * Non-vital response of pulp tissue. * Radiographic evidence of periapical lesions (minimum size 2.0 mm × 2.0 mm) related to one root in case of multi-rooted teeth. * Asymptomatic patients. 4. Positive patients' acceptance for participation in the study.

Exclusion criteria

1. Primary teeth, and permanent teeth with immature apex. 2. Teeth previously accessed or endodontically treated. 3. Patients with diabetes and immune-compromising disease. 4. Patients allergic to metronidazole, ciprofloxacin, or minocycline. 5. Vital cases or necrotic without periapical lesion. 6. Pregnant women. 7. Teeth with unfavorable conditions for rubber-dam application. 8. Tooth associated with vertical root fracture, coronal perforation, calcification and external or internal root resorption.

Design outcomes

Primary

Measure	Time frame	Description
postoperative pain	24 hours	using numerical rating scale from 0-10

Secondary

Measure	Time frame	Description
Radiographic healing	3 months	using digital radiography

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 2, 2026