Cerebral Cavernous Malformation, Intracerebral Hemorrhage
Conditions
Brief summary
The aim of this prospective study is to reveal the natural history of symptomatic hemorrhage in adult patients with cerebral cavernous malformation with the goal of informing the treatment plan.
Detailed description
Cerebral cavernous malformation Patients with newly diagnosed, cerebral cavernous malformation who will visit one of the study centers during the period from June 2016 to December 2017. Patients would be eligible for enrollment if they were 18 years of age or older and had at least 1 cerebral cavernous malformation. If the patient had multiple cavernous malformations, index cavernous malformation would be enrolled. Index lesion will be determined according to the criteria. * Index lesion decision criteria I. Symptomatic II. Asymptomatic (priorities are as follows) 1. Previous bleed 2. Brain stem location 3. Deep nuclei (thalamus, caudate, basal ggl, hypothalamus) 4. Periventricular 5. Largest All patients who would visit a study center during the enrollment period and meet these criteria will be asked to join the study. The cohort will consists of patients who agree to participate. Target population of this study is 228 patients.
Interventions
None listed
Sponsors
Asan Medical Center
KangWon National University Hospital
Jeju National University Hospital
Chuncheon Sacred Heart Hospital
SMG-SNU Boramae Medical Center
Gyeongsang National University Hospital
Soonchunhyang University Hospital
Johannes Gutenberg University Mainz
First Affiliated Hospital of Suzhou Medical College
Seoul National University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients with newly diagnosed cerebral cavernous malformation who agreed to participate. * 18 years old or more
Exclusion criteria
* Patients who underwent treatment(surgery or radiosurgery) for cavernous malformation * Patients who are accompanied by other serious medical problems
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Symptomatic hemorrhage | 5 year | hemorrhage due to rupture of cavernous malformation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Symptomatic hemorrhage | 1 year | hemorrhage due to rupture of cavernous malformation |
| All hemorrhagic event including radiologic rupture + newly appeared neurologic symptom | 1 year | hemorrhage without symptom |
| All hemorrhagic event including radiologic rupture | 5 year | all hemorrhagic events |
Countries
South Korea
Outcome results
None listed