Heart Failure, Diastolic, Heart Failure, Systolic
Conditions
Brief summary
To better understand the public health prognostic impact of noncardiac chronic illnesses, we explored the attributable risk of noncardiac comorbidities on outcomes between heart failure patients with reduced ejection fraction (HFREF) and heart failure patients with preserved ejection fraction (HFpEF) in a large contemporary heart failure (HF) population The adjusted hazard ratio (HR) and the population attributable risk were used to compare the contributions of 15 noncardiac comorbidities to adverse outcome. The comorbidities that contributed to high attributable risk were: anemia, chronic kidney disease, chronic obstructive pulmonary disease, diabetes mellitus, and peripheral artery disease. These findings were similar for HFrEF and HFpEF groups. Interaction analysis confirmed similar results.
Interventions
OTHERprognostic impact of non cardiac comorbidities
Sponsors
Ospedale Maggiore Di Trieste
Study design
Observational model
ECOLOGIC_OR_COMMUNITY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All consecutive heart failure patients with left ventricular ejction fraction available before or within 3 months from the index visit
Exclusion criteria
* We excluded all patients who had severe primary left-sided valvular disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| overall mortality | 2 years |
Secondary
| Measure | Time frame |
|---|---|
| First all-cause hospitalization | 2 years |
| Heart Failure hospitalization | 2 years |
| noncardiovascular hospitalization | 2 years |
Outcome results
None listed