Postoperative Pain
Conditions
Brief summary
The purpose of this study is to compare the analgesic profile of modified pectoral nerves block and serratus plane block in patients undergoing mastectomy.
Detailed description
This study includes three groups. The first group will receive ultrasound-guided modified pectoral nerves block prior to induction of general anesthesia. The second one will receive ultrasound-guided serratus plane block prior to induction of general anesthesia. The third one will not receive any block preoperatively.
Interventions
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* American Society of Anesthesiologists( ASA) I or II and scheduled for major breast cancer surgery( modified radical mastectomy or conservative mastectomy with axillary evacuation).
Exclusion criteria
* Local infection at the site of the block, coagulations abnormalities, allergy to local anesthetics or morphine, body mass index\> 35, patient refusal, severe respiratory or cardiac disorders, pre-existing neurological deficits, hepatic or renal insufficiency, chronic pain syndrome, chronic analgesic use and psychiatric disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fentanyl consumption | Intraoperative |
| Total morphine consumption | The first 24 hours postoperative |
| Visual analogue scale score at rest and during shoulder movement | The first 24 hours postoperative |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Sedation score | Immediate postoperative, 1, 4, 8, 12, 24 hours postoperative | as a side effect of morphine |
| Respiratory rate | Immediate postoperative, 1, 4, 8, 12, 24 hours postoperative | respiratory depression defined as respiratory rate \<12 breaths per minute |
| Mean arterial blood pressure | Preincision, 1 minute postincision, 1 hour postincision, 4, 8, 12, 24 hours postoperative | Hemodynamics |
| Patient satisfaction with postoperative analgesia | One week after surgery | using numerical rating scale from 0 to 10 |
| Nausea and vomiting | The first 24 hours postoperative | as a side effect of morphine |
| Heart rate | Preincision, 1 minute postincision, 1 hour postincision, 4, 8, 12, 24 hours postoperative | Hemodynamics |
| Time to first requirement of rescue analgesia | The first 24 hours postoperative | — |
Countries
Egypt
Outcome results
None listed