Cerebral Palsy
Conditions
Keywords
motor skill learning, visuo-spatial attention
Brief summary
This study aims to investigate the changes induced by HABIT-ILE in impairments, activity and participation of children with unilateral CP, as well as neuroplastic changes induced by the treatment. Visuospatial deficits will be investigated and the effect of prismatic adaptation will be measured.
Detailed description
This study aims to investigate the changes induced by HABIT-ILE at the 3 levels of the international classification of functioning and health (ICF) in children with unilateral CP, as well as neuroplastic changes induced by the treatment. Visuospatial deficits will be investigated and the effect of prismatic adaptation will be measured.
Interventions
BEHAVIORALHABIT-ILE with prismatic adaptation
Bimanual and locomotor intensive intervention for 90h including 8 hours of prismatic adaptation
BEHAVIORALHABIT-ILE without prismatic adaptation
Bimanual and locomotor intensive intervention for 90h including 8 hours of prismatic adaptation wearing sham goggles.
Sponsors
Université Catholique de Louvain
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
5 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
* unilateral CP * minimal ability to pick an light object from a table * age 5-18
Exclusion criteria
* no active seizure * no botox or orthopedic intervention in the 6 months preceding the study or during the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| changes in star cancellation | at baseline and after 90 hours/two weeks of intensive bimanual intervention | number of little stars omitted in a frame including many stars of different size |
| change in Ogden Figure test | at baseline and after 90 hours/two weeks of intensive bimanual intervention | number of elements omitted when reproducing a drawing |
| changes in line bissection | at baseline and after 90 hours/two weeks of intensive bimanual intervention | deviation from midline during line section |
| visuo-spatial pointing | at baseline and after 90 hours/two weeks of intensive bimanual intervention | pointing in a blind box in the direction of a visual cue, measuring the deviation from midline |
| proprioceptive pointing | at baseline and after 90 hours/two weeks of intensive bimanual intervention | pointing without any visual feedback in the direction of body midline and measuring deviation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| ABILHAND-Kids questionnaire | at baseline and after 90 hours/two weeks of intensive bimanual intervention | parents-reported questionnaire measuring manual ability |
| Jebsen-Taylor test of hand function | at baseline and after 90 hours/two weeks of intensive bimanual intervention | Manual dexterity measured with objects of everyday life, measure=time to manipulate objects |
| Canadian Occupationnal Performance Measure | at baseline and after 90 hours/two weeks of intensive bimanual intervention | setting therapeutic goals with parents and measuring both performance and satisfaction (%) |
| ACTIVLIM-CP questionnaire | at baseline and after 90 hours/two weeks of intensive bimanual intervention | parents-reported questionnaire measuring global activity performance |
| functional magnetic resonance imaging (fMRI) | at baseline and after 90 hours/two weeks of intensive bimanual intervention | cortical activation (changes in voxels activation) |
| Box and blocks | at baseline and after 90 hours/two weeks of intensive bimanual intervention | number of blocks manipulated in one minute |
| Assisting Hand Assessment | at baseline and after 90 hours/two weeks of intensive bimanual intervention | help provided by the paretic hand to the non-paretic one in bimanual coordination |
| diffusion tensor imaging (DDTI) | at baseline and after 90 hours/two weeks of intensive bimanual intervention | measuring changes in white matter tracts (fractional anisotropy, number of voxels) |
Countries
Belgium
Outcome results
None listed