Depression, Unipolar, Depressive Disorder, Depressive Disorder, Major
Conditions
Keywords
depression, cognitive bias modification, MDD, major depressive disorder, attention bias modification treatment
Brief summary
The purpose of this study is to determine whether giving gaze-contingent feedback is an effective attention modification procedure, helping in the treatment of Major Depressive Disorder (MDD)
Detailed description
The study examines giving depressive participants gaze-contingent feedback as a novel attention training procedure. Half of the participants will receive contingent feedback while the other half would receive non-contingent placebo feedback.
Interventions
BEHAVIORALAttention Modification
Feedback according to participants' viewing patterns, in order to modify their attention.
Sponsors
Tel Aviv University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* A signed consent form * Men and women between the ages of 18 and 65. * Meeting a current diagnosis of Major Depressive Disorder (MDD) according to the DSM-IV * MDD as the primary diagnosis: In cases of co-morbidity, MDD will be deemed as the most distressing and clinically significant condition among the co-morbid disorders * Stable pharmaco-therapy: Participants receiving a pharmacological treatment who are taking a stable medication for at least 3 months before the beginning of the procedure.
Exclusion criteria
* Psychotic episode in the past or the present time. * Co-morbidity with any neurological disorder (i.e., epilepsy, brain injury). * Another psychotherapeutic treatment during the study. * Usage of neuroleptic medication. * Change in medication status during the study. * Substantial usage of drugs or alcohol in the present time. * Poor judgment capacity (i.e., children under 18 and special populations). * High Risk of Suicide.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline - Structured Interview for the Montgomery-Asberg Depression Rating Scale (SIGMA) | post treatment (1 week after treatment completion) and 3-month follow up | The SIGMA is a ten-item diagnostic structured interview which psychiatrists use to measure the severity of depressive episodes in patients with mood disorders. Each item is rated on scale ranging from 0 to 6 with a possible total score of 60, with regard to the passing week. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline - BDI-II - Beck Depression Inventory | post treatment (1 week after treatment completion) and 3-month follow up | The BDI -II is a 21-question multiple-choice self-report inventory. Each item is rated on scale ranging from 0 to 3, Higher total scores indicate more severe depressive symptoms. |
Other
| Measure | Time frame | Description |
|---|---|---|
| changes in the Mini-International Neuropsychiatric Interview (M.I.N.I) diagnosis | approximately 20 min | a structured diagnostic interview for DSM - IV and ICD-10 psychiatric disorders, which takes approximately 20 min to administer and is a valid and time-efficient alternative to the SCID-P and CIDI. |
Countries
Israel
Outcome results
None listed