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Treatment of Peri-calcification Edema in Neurocysticercosis (NCC)

Open Controled Randomized Pilot Study on the Use of Acetazolamide and Dexamethasone for the Acute Phase of Perilesional Edema in Calcified Neurocysticercosis

Status
Terminated
Phases
Phase 2Phase 3
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02945527
Enrollment
4
Registered
2016-10-26
Start date
2015-12-04
Completion date
2018-12-31
Last updated
2025-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neurocysticercosis

Brief summary

Three-arm open, randomized comparative study of acetazolamide, dexamethasone, or no additional treatment to evaluate decrease in peri-calcification edema in neurocysticercosis

Detailed description

This study will evaluate 24 patients with calcified NCC and edema in three treatment arms to compare the reduction in edema volume

Interventions

DRUGAcetazolamide

As described above

DRUGDexamethasone

As described above

Sponsors

Universidad Peruana Cayetano Heredia
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

* Calcified NCC * Perilesional edema on CT or MRI * Normal lab values

Exclusion criteria

* Viable neurocysticercosis * Status epilepticus * Symptomatic intracranial hypertension * Tuberculosis * More than 7 days after seizure * Pregnancy

Design outcomes

Primary

MeasureTime frameDescription
Decrease in Volume of Perilesional Edema Between Baseline and Day 4Baseline to Day 4MRI extension of edema

Secondary

MeasureTime frameDescription
Decrease in Volume of Perilesional Edema Between Baseline and Day 8Baseline to Day 8MRI extension of edema
Decrease in Volume of Perilesional Edema Between Baseline and Day 30Baseline to Day 30MRI extension of edema

Countries

Peru

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026