Pancreas Cancer
Conditions
Keywords
MRI
Brief summary
This study aims to establish radiomics database for pancreas cancer from multiparametric MRI including DCE-MRI obtained by using incoherent undersampling and radial acquisition for clinical staging as well as quantitative analysis.
Interventions
PROCEDUREmulti-parametric MRI
multiparametric MRI is performed in all patients, and the sequence includes dynamic contrast enhanced (DCE) MRI, diffusion weighted imaging (DWI), tissue maps, and MR cholangiography.
Sponsors
Seoul National University Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* surgical candidate for pancreatico-duodenectomy * characteristic finding of pancreatic adenocarcinoma on prior CT or MRI * OR histologically diagnosed with pancreatic adenocarcinoma * signed for informed consent
Exclusion criteria
* under 18 years * not eligible for pancreatico-duodenectomy * unresectable patients (locally advanced on prior CT/MRI or metastatic disease) * tumors with suspicion of other histologic types (neuroendocrine, IPMN, etc) * any contra-indication of contrast-enhanced MRI * recurred pancreatic cancer
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| T-staging | 4 weeks after MR acquisition | T-staging of the tumor at MRI. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| arterial blood flow | 4 weeks after MR acquisition | arterial blood flow of the tumor and adjacent parenchma on DCE-MRI |
| arterial fraction | 4 weeks after MR acquisition | arterial fraction of the tumor and adjacent parenchyma on DCE-MRI |
| mean transit time | 4 weeks after MR acquisition | mean transit time of the tumor and adjacent parenchyma on DCE-MRI |
| extracellular volume | 4 weeks after MR acquisition | extracellular volume of the tumor and adjacent parenchyma on DCE-MRI |
| true diffusion | 4 weeks after MR acquisition | true diffusion of the tumor and adjacent parenchyma on DWI with intravoxel incoherent motion model |
| pseudodiffusion | 4 weeks after MR acquisition | pseudodiffusion of the tumor and adjacent parenchyma on DWI with intravoxel incoherent motion model |
| perfusion fraction | 4 weeks after MR acquisition | perfusion fraction of the tumor and adjacent parenchyma on DWI with intravoxel incoherent motion model |
| kurtosis | 4 weeks after MR acquisition | kurtosis of the tumor and adjacent parenchyma on DWI with kurtosis model |
| mean diffusivity | 4 weeks after MR acquisition | mean diffusivity of the tumor and adjacent parenchyma on DWI with kurtosis model |
| N-staging | 4 weeks after MR acquisition | N-staging of the tumor at MRI |
Other
| Measure | Time frame | Description |
|---|---|---|
| T1 value | 4 weeks after MR acquisition | T1 value of the tumor and adjacent parenchyma using T1 map |
| T2 value | 4 weeks after MR acquisition | T1 value of the tumor and adjacent parenchyma using T2 map |
| fat fraction | 4 weeks after MR acquisition | fat fraction of the tumor and adjacent parenchyma using T2\* corrected fat map |
| global textural feature | 4 weeks after MR acquisition | first order parameters related to the grey level frequency distribution in the region of interest using dedicated software |
| local textural feature | 4 weeks after MR acquisition | second order parameters calculated with spatial grey level dependence matrices or co-occurrence matrices using dedicated software |
| attenuation | 4 weeks after MR acquisition | hounsefield unit (HU) of the tumor and parameter on CT within 4 weeks of MRI |
| transient dyspnea | 1 day after MR acquisition | development of transient dyspnea or involuntary motion after contrast media administration |
Countries
South Korea
Outcome results
None listed