The Impact of Botulinum Toxin on Brow Height and Morphology: A Randomized Controlled Trial

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02942303

Enrollment

Registered

2016-10-24

Start date

2016-10-31

Completion date

2017-05-31

Last updated

2017-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brow Lifting

Keywords

Botulinum Toxin, Rejuvenation, Brow lift, Eyebrow.

Brief summary

The purpose of this study is to describe three safe and reproducible techniques for brow lifting using botulinum toxin. It will also describe the effect of 2 techniques on the eyebrow shape using quantitative, objective measurements and satisfaction scales.

Interventions

DRUGDysport

PROCEDURElateral orbicularis injection

PROCEDURELateral orbicularis + corrugator injection

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

28 Years to 50 Years

Healthy volunteers

Inclusion criteria

* Consecutive 30 female patients presenting to our clinic for brow lifting with botulinum toxin will be randomized to receive one of the two injection techniques

Exclusion criteria

* Patients with previous periorbital/forehead surgery * Patients who plucked the upper eyebrow margin * Patients with eyebrow tatoos * Patients with upper face botulinum toxin injection in the past 12 months * Patients with resorbable upper face fillers injection in the past 12 months * Patients with previous permanent upper face fillers injection * Pregnant patients * Lactating patients * Patients with preexisting neuromuscular conditions (myasthenia gravis, Eaton Lambert syndrome) * Patients using medication that could potentiate the effect of botulinum (ex: aminoglycoside antibiotics) * Patients with sensitivity to botulinum toxin or human albumin

Design outcomes

Primary

Measure	Time frame	Description
Objective assessment	15 days post treatment	Objective assessment will be done on anteroposterior views of pre-and-post injection photographs. The mid pupillary line will be drawn and the eyebrow vertical height will be measured from this line to the upper border of the brow at seven horizontal points: the most medial aspect of the eyebrow, medial canthus, medial limbus, mid pupil, lateral limbus, lateral sclera, and most lateral eyebrow.

Secondary

Measure	Time frame	Description
Patient satisfaction	15 days post treatment	Patient satisfaction will be determined by a questionnaire completed at 15 days post-treatment. Subjects will indicate how satisfied they are on a 4-point scale (1-4) as follow: 1. Very Satisfied 2. Satisfied 3. Dissatisfied 4. Very Dissatisfied.

Countries

Lebanon

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026