Piezoelectric Vibrations and Tissue, Cellular and Molecular Mechanisms of Oral Wound Healing After Third Molar Surgery

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02942108

Enrollment

Registered

2016-10-21

Start date

2016-10-31

Completion date

2020-04-30

Last updated

2022-12-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tooth, Impacted

Keywords

piezolectric surgery, conventional surgery, lower third molars

Brief summary

The aim of this clinical trial is to investigate and compare the effect of piezoelectric surgery on tissue, cellular and molecular level of oral surgical wound healing and postoperative outcomes (pain, swelling, trismus) after lower third molar surgery in healthy patients

Interventions

PROCEDUREpiezo surgery

PROCEDUREconventional surgery

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* bilaterally symmetrically impacted lower third molars

Exclusion criteria

* presence of intraoral infection * chronic orofacial pain * pregnancy/ lactation * heavy tobacco smokers * alcohol/ drug abuse * allergic reaction to medicaments used

Design outcomes

Primary

Measure	Time frame	Description
SOD activity in alveolar bone specimen	immediately after surgery	Activity of enzyme superoxide dismutase in bone specimens obtained during lower third molar surgery
VEGF levels in alveolar bone specimen	immediately after surgery	—
MMP-9 level in alveolar bone specimen	immediately after surgery	—

Countries

Serbia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026