Ischemic Heart Disease
Conditions
Keywords
coronary artery bypass grafting, cardiopulmonary bypass, Cerebral oxidative stress, Cerebral inflammatory stress, Cerebral hemodynamics, Postoperative cognitive dysfunction
Brief summary
Purpose: The purpose of this study is to examine cerebral oxidative and inflammatory stress and cerebral hemodynamics during and after coronary artery bypass grafting and correlate with postoperative cognitive function.
Detailed description
Postoperative cognitive decline is a well-known and well-described complication following coronary artery bypass grafting. Severity ranges from postoperative delirium to stroke, but the majority of patients with postoperative cognitive decline following coronary artery bypass grafting have decline in recent and remote memory in particular. The reason for the cognitive decline is still not fully understood though many reasons have been proposed. Inflammation and oxidative stress may contribute to the postoperative cognitive dysfunction which may also be in combination with a reduced cerebral autoregulation.
Interventions
None listed
Sponsors
Rigshospitalet, Denmark
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Patients with ischemic heart disease admitted for coronary artery bypass grafting with the use of cardiopulmonary bypass
Exclusion criteria
* Cerebrovascular disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cerebral autoregulation | 6 hours post operation | Flow measurement of middle cerebral artery and measurement of middel arterial pressure |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative cognitive function | One day prior to operation and three days after operation |
Outcome results
None listed