Thoracic Surgery, Thromboprophylaxis
Conditions
Brief summary
Thromboembolism is an important perioperative complication in major thoracic surgery, even though current guidelines have recommended postoperative administration of heparin or LMWH for thromboprophylaxis for those high-risk patients, there are still many cases of thromboembolism. Therefore, as the guideline itself writes, the investigators believe the rational of dose and timing of heparin in thoracic surgery are still not well established. Therefore, the investigators aimed to conduct this randomized controlled study to explore the safety and efficacy of preoperative Administration of Heparin as Thromboprophylaxis in Major Thoracic Surgery.
Interventions
DRUGHeparin
Sponsors
West China Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* 18-75 years old without any preoperative VTEs; * patients undergoing major thoracic surgery (including lobectomy, esophagectomy, and thymectomy).
Exclusion criteria
* patients with coagulation disorders: preoperative international normalized ratio (INR) \> 1.5, or blood platelet count \< 50x10\^9/L; * patients receiving any therapeutic anticoagulation preoperatively; * patients with severe renal or liver dysfunction.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| chest tube drainage duration (days) | from postoperative day 1 to chest tube remove(usually on postoperative day 3 for lobectomy or thymectomy,on postoperative day 7 for esophagectomy ) | — |
| APTT (s) | on postoperative day 1 for both group | — |
| PT(s) | on postoperative day 1 for both group | — |
| INR | on postoperative day 1 for both group | — |
| blood platlet count(/L) | on postoperative day 1 for both group | — |
| intraoperative bleeding volume (ml) | the bleeding volume (ml) during operation in the operation room for all patients | During the operation, the blood loss of each patient was collected and measured, and recorded by the investigators. |
| chest tube drainage volume (ml) | from postoperative day 1 to chest tube remove(usually on postoperative day 3 for lobectomy or thymectomy,on postoperative day 7 for esophagectomy ) | — |
| thromboembolism occurence rate (%) | within 30 days after surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| APTT(s) | rightly upon hospital admission day |
| INR | rightly upon hospital admission day |
| blood platlet count(/L) | rightly upon hospital admission day |
| PT(s) | rightly upon hospital admission day |
Countries
China
Contacts
Primary ContactYi-Dan Lin, MD
Backup ContactHan-Yu Deng, MD
Outcome results
None listed