Stem Cell Transplantation
Conditions
Brief summary
The combined analysis of microbiome, immunological parameters and host genetics in patients has potential for applying personalized approaches of prevention, diagnostics or therapy in the future. However, the acquisition and analysis of these patient characteristics in a scientifically sound, technically reliable, cost-effective, practicable and future-oriented fashion are a far from trivial task. Therefore the objectives of the study are (i) to optimize a sample and data acquisition and analysis pipeline that fulfills these criteria (using samples from healthy volunteers); (ii) validate the pipeline in a cohort of children undergoing stem cell transplantation, yielding information on host immuno-genetics, gut immune function and the human gut microbiome; (iii) deduct the most critical parameters for host-microbiome interplay from this complex dataset.
Interventions
OTHERStem cell transplantation
Intervention is not conducted as part of the study but patients at Tübingen University Hospital undergoing this intervention as part of their standard care are being monitored in this observational study.
Sponsors
University Hospital Tuebingen
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
3 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* Patient (stem cell recipient) with hematological malignancies, age 3-18 * Healthy allogeneic stem cell donor (identical or non-identical related donor)
Exclusion criteria
* Patients \<3 years of age * Patient who are unable to provide urine, stool or blood samples due to their medical condition
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Immune system - intestinal microbiota co-re-emergence after myeloablative conditioning and antibiotics treatment, respectively. | through study completion, anticipated after 2 years |
Countries
Germany
Contacts
Primary ContactAlexander NR Weber, PhD
Backup ContactSilke Peter, MD
Outcome results
None listed