Postprandial Glycemia
Conditions
Brief summary
A randomized, single-blind cross-over clinical nutrition trial will be conducted. The effects of yellow-fleshed potatoes and yellow-fleshed potatoes supplemented with anthocyanins extracted from purple-fleshed potatoes on healthy men's postprandial glycemia and insulinemia will be compared. Additionally, the postprandial metabolism and metabolites, and the appearance and metabolism of the flavonoids and their metabolites is studied in plasma, urine and feces.
Interventions
OTHERDietary
Sponsors
University of Turku
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
MALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 18-45 * Male * No regular medication * No participation in a drug trial or blood donation within 2 months * Non-smoker * Signs informed consent * Body mass index 18.5-27 kg/m2 * Fasting plasma cholesterol \< 5.5 mmol/l * Fasting plasma triacylglycerols \< 2.6 mmol/l * Fasting plasma glucose 4-6 mmol/l * blood pressure \<140/80 mmHg * hemoglobin\>130 g/l * Fasting plasma alanine amino transferase (ALAT) \<60 U/l (normal liver function) * Fasting plasma thyroid-stimulating hormone (TSH) 0.4 - 4.5 mU/l (normal thyroid function) * Fasting plasma creatinine \<118 µmol/l (normal kidney function)
Exclusion criteria
* Regular smoking * Alcohol abuse * Regular medication
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma glucose concentration | 0min, 20min, 40min, 60min, 90min, 120min, 180min, 240min |
| Plasma insulin concentration | 0min, 20min, 40min, 60min, 90min, 120min, 180min, 240min |
Secondary
| Measure | Time frame |
|---|---|
| Concentrations and quality of metabolites and flavonoid color compounds and their metabolites in plasma (NMR and (U)HPLC-MS/MS measurements) | 0min, 20min, 40min, 60min, 90min, 120min, 180min, 240min |
| Concentrations and quality of metabolites and flavonoid color compounds and their metabolites in urine (NMR and (U)HPLC-MS/MS measurements) | Before meal, and 0-4h, 4-8h, 8-16h, 16-24 h |
| Concentrations and quality of metabolites and flavonoid color compounds and their metabolites in feces (NMR and (U)HPLC-MS/MS measurements) | before and after meal |
| Area under the glucose concentration curve (AUC) | 0min, 20min, 40min, 60min, 90min, 120min, 180min, 240min |
| Area under the insulin concentration curve (AUC) | 0min, 20min, 40min, 60min, 90min, 120min, 180min, 240min |
Countries
Finland
Outcome results
None listed