Residual Neuromuscular Blockade in Pediatric Anesthesia

Residual Neuromuscular Blockade in Paediatric Patients Before Extubation and in Postanesthetic Care Unit:Prospective Observational Cohort Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02939911

Acronym

REPEB

Enrollment

291

Registered

2016-10-20

Start date

2017-01-31

Completion date

2017-12-31

Last updated

2018-11-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Residual Neuromuscular Blockade

Keywords

Residual neuromuscular blockade

Brief summary

Residual neuromuscular blockade (RNB) is frequent and it is associated with postoperative morbidity and mortality. The incidence of the RNB in pediatric anesthesia is currently not known. The aim of this prospective observational cohort study is to evaluate the early RNB just before extubation and late RNB at the time of arrival to postanesthetic care unit (PACU).

Detailed description

Residual neuromuscular blockade (RNB) is frequent and it is associated with negative impact on postoperative morbidity and mortality. The incidence of the RNB in adult is well described, however in pediatric subpopulation it is currently not known. The aim of this prospective observational cohort study is to evaluate the early RNB just before extubation and late RNB at the time of arrival to postanesthetic care unit (PACU). In the trial will be enrolled all pediatric patients (28 weeks of age and older - 19 years old) whom will be administered neuromuscular blocking agent during anesthesia. The demographic data will be collected including: age, weight, type of surgery, ASA status. The anesthesia management will be described including: airway management, type and cumulative dose of neuromuscular blocking agent (NMBA) and time and dose of the last administered bolus of NMBA. The residual neuromuscular blockade will be measured according to the standards: TOF Watch accelerometry at the moment prior to extubation (two measurements) in TOF mode and at the arrival to postanesthetic care unit (PACU) (two measurements) in TOF mode.

Interventions

DEVICEResidual neuromuscular blockade measurement

Just prior extubation in OR and at the arrival to PACU the residual neuromuscular blockade will be measured by accelerometry

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

29 Weeks to 19 Years

Healthy volunteers

Inclusion criteria

* Paediatric patients undergoing surgery with neuromuscular blocking agents were administered with the age limits

Exclusion criteria

* weight under 3000 grams * neuromuscular disease * haemodynamic impairment (vasopressor need) * planned postoperative mechanical ventilation

Design outcomes

Primary

Measure	Time frame	Description
Early residual neuromuscular blockade	before extubation	Just prior extubation the residual neuromuscular blockade will be measured by accelerometry

Secondary

Measure	Time frame	Description
Late neuromuscular blockade	at arrival to PACU	At the arrival to PACU the residual neuromuscular blockade will be measured by accelerometry

Countries

Czechia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026