Meningiomas
Conditions
Brief summary
Patients undergoing meningeoma resection surgery will be randomly assigned to two groups. One group will receive scalp nerve blocks with 0.5% ropivacaine, whereas the other group will receive scalp nerve blocks with 0.9% saline after anesthesia induction and before skull-pin insertion. Serum levels of TNF-α、IL-6 and IL-1β will be measured and compared at before surgery, 1h, 24h and 72h after surgery, respectively. VAS score, dosage of pain-control medicine and NRS score at the first three days after surgery, ratio of intracranial infection within 30d after surgery, and total hospitalization days and medical expenditure will also be recorded and compared between the two groups.
Interventions
PROCEDUREScalp Nerve Blocks With Ropivacaine
PROCEDUREScalp Nerve Blocks With Saline
Sponsors
RenJi Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* BMI 18-28 kg/m2 ASA Physical Status 1-2 diagnosed Meningeoma and will have selective Meningeoma Resection Surgery the incision will be conducted at the frontal, top or the temperal skull.
Exclusion criteria
* previous brain surgery severe systemic disease (heart, lung, kidney, or immune system) nerval or mental disorders a history of addiction to opioids allergic to ropivacaine infection at block site or severe systemic infection refuse to attend the trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| serum TNF-α level | 24 hour after surgery |
| serum IL-6 level | 24 hour after surgery |
| serum IL-1β level | 24 hour after surgery |
Secondary
| Measure | Time frame |
|---|---|
| VAS score | 24 hour after surgery |
| dosage of pain-control medicine | within 72 hour after surgery |
| NRS score | 24 hour after surgery |
| serum TNF-α level | 1 hour after surgery |
| Hospitalization Days | up to 30 days |
| out of pocket expenditure for hospitalisation | hospital discharge/up to 30 days |
| incidence of intracranial infection | within 30 days after surgery |
| serum IL-6 level | 1 hour after surgery |
| serum IL-1β level | 1 hour after surgery |
Countries
China
Outcome results
None listed