Acute Lower Gastrointestinal Dysfunction
Conditions
Keywords
Acute lower gastrointestinal dysfunction, Colon-originated lesions, Critical patient, Colonoscopic decompression, Anticholinergic drugs
Brief summary
This prospective study was designed to compare the difference of effects of conventional treatment, medicine intervention, endoscopic therapy, and surgery between colon originated and non-colon originated ALGID in critical patients, in order to alert doctors to differ the treatment of the two ALGID and provide basis for treatment.
Interventions
OTHERColon originated: Neostigmin, Colonoscopy decompression, Surgery
OTHERNon-colon originated: Neostigmin, Colonoscopy decompression
Sponsors
Chinese Medical Association
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
1. Patients in our ICU aged 18-75 years. 2. Patients with a confirmed diagnosis of ALGID.
Exclusion criteria
1. mechanical intestinal obstruction (including tumor, stercoral obstruction etc.) 2. gastrointestinal hemorrhage within 72 hours. 3. history of inflammatory bowel disease (ulcerative colitis or Crohn's disease) or radiation enteritis. 4. pregnancy. 5. contraindications of neostigmine administration.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day mortality after admission | 1-28 day after admission |
| ICU mortality, n (%) | 1-28 day after ICU admission |
Secondary
| Measure | Time frame |
|---|---|
| ICU stage, (day) | 1-60 day after ICU admission |
| Hospitalization, (day) | 1-60 day after admission |
| intra-abdominal pressure | 1-28 day after admission |
| Abdominal compartment syndrome | 1-28 day after admission |
Countries
China
Contacts
Primary ContactChenyan Zhao, M.D
Outcome results
None listed