Cancer of the Prostate
Conditions
Keywords
prostate, cancer, MRI
Brief summary
This is a pilot study taking place at University Hospitals of North Midlands NHS Trust. Patients referred for MRI for possible prostate cancer will be invited to take part in the study. Following consent, participants will have an additional MRI sequence performed during their routine MRI called Double Inversion Magnetic Resonance Imaging (DIR-MRI). Participants scan images and prostate biopsy histology report (if applicable) will be reviewed by the research team.
Detailed description
This is a pilot study taking place at University Hospitals of North Midlands NHS Trust. Patients referred for MRI for possible prostate cancer will be invited to take part in the study. Following consent, participants will have an additional MRI sequence performed during their routine MRI called Double Inversion Magnetic Resonance Imaging (DIR-MRI). Participants scan images and prostate biopsy histology report (if applicable) will be reviewed by the research team. The research team will look at the variability of LNR score amongst the two scan typed and the DCE-MRI and DIR-MRI images will be correlated with biopsy results to give an indication of the accuracy.
Interventions
OTHERMagnetic Resonance Imaging
Double Inversion Recovery Magnetic Resonance Imaging (DIR-MRI) and Dynamic Contrast Enhanced Magnetic Imaging (DCE-MRI)
Sponsors
University Hospitals of North Midlands NHS Trust
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients referred for prostate MRI for possible prostate cancer * Safe to undergo an MRI scan * Able to give informed consent
Exclusion criteria
* MRI referrals where prostate cancer is not the question * Patients who are not safe to undergo an MRI scan * Patients who have undergone prostate biopsy in the previous 10 weeks * Patients unable to give informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Lesion to Normal tissue Ratio (LNR) recorded for DIR-MRI and DCE-MRI | 3 months | In order to inform a sample size calculation for a subsequent, fully powered equivalence trial Is DIR-MRI equivalent to DCE-MRI in detection of prostate cancer |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation of biopsy and DIR-MRI and DCE-MRI findings | 3 months | In order to ascertain if addition of DIR-MRI could improve accuracy of cancer diagnosis |
Countries
United Kingdom
Outcome results
None listed